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Table 2 5-year Overall Survival and Disease-Specific Survival by Anatomic and Prognosis Stage of TNBCs included in SEER cohort (N = 31,941)

From: AJCC 8th edition prognostic staging provides no better discriminatory ability in prognosis than anatomical staging in triple negative breast cancer

 

Stage

No. at risk

5-year OS (95% CI)

p-value

No. at risk

5-year DSS (95% CI)

p-value

AS

I

12,700

87.2(86.2,88.0)

< 0.001**

12,700

93.5(82.8,94.2)

< 0.001**

 IA

12,293

87.4(86.5,88.3)

0.004*

12,293

93.8(93.1,94.4)

0.001*

 IB

407

80.4(73.9,85.5)

 

407

86.2(80.6,90.2)

 

II

14,292

75.3(74.2,76.4)

< 0.001#

14,292

82.7(81.8,83.7)

< 0.001#

 IIA

9713

78.5(77.2,79.7)

 

9713

86.0(84.9,87.0)

 

 IIB

4579

68.3(66.1,70.4)

 

4579

75.5(73.5,77.4)

 

III

4949

46.8(44.8,48.7)

< 0.001

4949

54.0(52.0,56.0)

< 0.001

 IIIA

2515

57.1(54.3,59.7)

 

2515

63.6(60.8,66.2)

 

 IIIB

1164

38.5(34.5,42.5)

 

1164

47.0(42.6,51.2)

 

 IIIC

1270

34.3(30.5,38.2)

 

1270

41.4(37.3,45.2)

 

PS

I

12,293

87.4(86.5,88.3)

< 0.001**

12,293

93.8(93.1,94.4)

< 0.001**

 IA

407

89.4(83.6,93.2)

0.212*

407

94.6(89.2,97.3)

0.259*

 IB

11,886

87.4(86.5,88.3)

 

11,886

93.8(93.1,94.4)

 

II

10,726

77.9(76.7,79.1)

< 0.001#

10,726

85.5(84.4,86.5)

< 0.001#

 IIA

10,120

78.6(77.3,79.8)

 

10,120

86.0(85.0,87.0)

 

 IIB

606

67.4(61.2,72.9)

 

606

75.4(69.3,80.4)

 

III

8922

56.3(54.8,57.8)

< 0.001

8922

63.5(62.0,65.0)

< 0.001

 IIIA

3986

68.7(66.4,70.8)

 

3986

75.6(73.4,77.6)

 

 IIIB

365

56.3(47.8,64.0)

 

365

62.1(53.0,70.0)

 

 IIIC

4571

45.9(43.9,48.0)

 

4571

53.3(51.2,55.4)

 
  1. **Log-rank test comparing proportions among all stage;*Log-rank test comparing proportions among Stage I; #Log-rank test comparing proportions among Stage II; Log-rank test comparing proportions among Stage III
  2. TNBC triple negative breast cancer, AS anatomic stage, PS prognosis stage, OS overall survival, DSS disease specific survival, CI confidence interval