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Table 1 5-year Progression-Free Survival and Disease-Specific Survival by Anatomic and Prognosis Stage of TNBCs included in SYSUCC-PWH cohort (N = 611)

From: AJCC 8th edition prognostic staging provides no better discriminatory ability in prognosis than anatomical staging in triple negative breast cancer

 

Stage

No. at risk

5-year PFS (95% CI)

p-value

No. at risk

5-year DSS (95% CI)

p-value

AS

I(A*)

100

86.5(76.2,92.5)

< 0.001**

100

92.9(83.4,97.0)

0.001**

II

371

82.0(77.0,86.0)

0.001#

371

90.6(86.3,93.6)

0.080#

 IIA

240

87.9(82.4,91.9)

 

240

92.7(87.7,95.7)

 

 IIB

131

71.0(60.9,79.0)

 

131

86.2(76.8,92.0)

 

III

140

50.9(41.1,59.8)

0.045

140

74.1(64.2,81.7)

0.099

 IIIA

78

56.6(43.7,67.6)

 

78

80.4(67.8,88.5)

 

 IIIB

29

55.2(28.6,75.4)

 

29

51.4(23.1,73.9)

 

 IIIC

33

34.9(18.3,52.2)

 

33

70.4(46.9,85.0)

 

PS

I

100

86.5(76.2,92.5)

< 0.001**

100

92.9(83.4,97.0)

< 0.001**

 IA

3

NA

NA

3

NA

NA

 IB

97

86.0(75.4,92.3)

 

97

92.7(88.5,97.0)

 

II

291

83.9(78.3,88.2)

0.002#

291

91.9(87.2,94.9)

0.209#

 IIA

240

87.9(82.4,91.9)

 

240

92.7(89.7,95.7)

 

 IIB

51

64.1(46.1,77.5)

 

51

87.3(79.4,95.1)

 

III

220

60.1(52.3,66.9)

< 0.001

220

78.2(70.7,83.9)

0.023

 IIIA

83

74.7(62.2,83.6)

 

83

85.5(78.7,92.3)

 

 IIIB

26

73.7(50.4,87.3)

 

26

83.5(72.5,94.5)

 

 IIIC

111

44.9(34.0,55.1)

 

111

70.7(61.8,79.7)

 
  1. **Log-rank test comparing proportions among all stage; #Log-rank test comparing proportions among Stage II; Log-rank test comparing proportions among Stage III; *No case was classified as anatomic stage IB in this cohort
  2. TNBC triple negative breast cancer, AS anatomic stage, PS prognosis stage, PFS progression-free survival, DSS disease specific survival, CI confidence interval