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Table 2 Comparison of apoptosis, necroptosis and pyroptosis

From: Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

 ApoptosisNecroptosisPyroptosis
InitiatingProgramRandomProgram
Signaling pathwayCaspase-3/7/8TNF-αCaspase-1/11
Terminal eventMembrane pore formationNoMLKLGSDMD
Cell swellingNoYesYes
PI stainingNoYesYes
LDH releaseNoYesYes
TUNELYesYesYes
Tissue effectInflammatoryNoYesYes
IL-1β releaseNoNoYes