Table 2 Comparison of apoptosis, necroptosis and pyroptosis
| Â | Apoptosis | Necroptosis | Pyroptosis | |
|---|---|---|---|---|
Initiating | Program | Random | Program | |
Signaling pathway | Caspase-3/7/8 | TNF-α | Caspase-1/11 | |
Terminal event | Membrane pore formation | No | MLKL | GSDMD |
Cell swelling | No | Yes | Yes | |
PI staining | No | Yes | Yes | |
LDH release | No | Yes | Yes | |
TUNEL | Yes | Yes | Yes | |
Tissue effect | Inflammatory | No | Yes | Yes |
IL-1β release | No | No | Yes | |