Diagnostic value of plasma HSP90α levels for detection of hepatocellular carcinoma

BMC Cancer

Table 2 Main parameters of ROC curve analysis results and the pairwise comparison of the ROC curves

Variable	AUC	95%CI	Sensitivity (%)	Specificity (%)	Cut-off	p
HCC-HD
AFP	0.922	0.902–0.938	81.18	93.91	5.38	< 0.001
HSP90α	0.836	0.810–0.860	67.07	90.43	69.10	< 0.001
AFP+ HSP90α	0.943	0.925–0.957	85.89	98.26		< 0.001
Pairwise comparison
AFP ~ HSP90α		0.057–0.115				< 0.001
AFP ~ AFP + HSP90α		0.006–0.036				< 0.005
HSP90α ~AFP + HSP90α		0.085–0.128				< 0.001
SHC-HD
AFP	0.597	0.543–0.649	56.14	62.61	2.68	0.003
HSP90α	0.735	0.685–0.781	56.14	86.96	64.70	< 0.001
AFP+ HSP90α Pairwise comparison	0.743	0.693–0.788	58.77	86.96		< 0.001
AFP ~ HSP90α		0.054–0.223				0.001
AFP~AFP + HSP90α		0.064–0.228				< 0.001
HSP90α~AFP + HSP90α		−0.004-0.012				0.203
HCC-SHC
AFP	0.889	0.864–0.910	76.9	92.10	7.83	< 0.001
HSP90α	0.601	0.566–0.636	63.00	54.40	75.45	0.001
AFP+ HSP90α Pairwise comparison	0.882	0.857–0.903	77.24	92.11		< 0.001
AFP ~ HSP90α		0.227–0.348				< 0.001
AFP~AFP + HSP90α		−0.008-0.022				0.341
HSP90α ~AFP + HSP90α		0.210–0.350				< 0.001

HD healthy donors; HH hepatic hemangioma patients; SHC secondary hepatic carcinoma patients; HCC hepatocellular carcinoma patients; AFP alpha-fetoprotein

ISSN: 1471-2407