Fig. 2

Scatter plot of TDS versus GLUT and glycolysis signatures in PTC and PDTC/ATC. (a, b) Pearson’s correlation analysis showed that negative correlation was shown between TDS and GLUT (r = − 0.59, p < 0.0001), while positive correlation was shown between TDS and glycolysis (r = 0.33, p < 0.0001). (c, d) GLUT and glycolysis signatures of BRAFV600E positive group showed no significant correlation with TDS (r = − 0.18, p = 0.065 and r = − 0.03, p = 0.605, respectively). (e, f) GLUT and glycolysis signatures of BRAFV600E negative group were significantly correlated with TDS in PTC (r = − 0.57, p < 0.001 and r = 0.35, p < 0.001, respectively). (g, h) Pearson’s correlation analysis showed that signatures of GLUT and glycolysis both have negative correlation with TDS in PDTC/ATC (r = − 0.68, p < 0.0001 and r = − 0.38, p = 0.019, respectively)