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Fig. 3 | BMC Cancer

Fig. 3

From: Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer

Fig. 3

LVSI-positive primary tumors resemble metastatic lesions, to which the infiltration of stromal cells contributes most. LVSI-positive samples were characterized by a reduced tumor purity and b remarkably elevated mesenchymal infiltration. Omental metastases displayed a similar trend compared to primary ovarian tumors c-d. The activation of the LMGS was e significantly negatively correlated with tumor purity and f positively correlated with mesenchymal infiltration in serous ovarian cancer samples from TCGA dataset. g The infiltration of fibroblasts was remarkably elevated in primary ovarian cancer samples with LVSI-positive status. A similar trend was observed in omental metastases compared with primary lesions in h dataset GSE2109 and was validated in i paired samples from dataset GSE30587

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BMC Cancer

ISSN: 1471-2407

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