Clinicopathological features | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age | 1.03 (1.02–1.04) | < 0.001 | 1.02 (1.01–1.03) | < 0.001 |
Sex | Â | 0.979 | Â | Â |
 Male | Reference |  |  |  |
 Female | 1.00 (0.83–1.21) |  |  |  |
BMI | 0.94 (0.92–0.97) | < 0.001 |  | 0.058 |
ASA score | Â | 0.013 | Â | 0.740 |
 1 | Reference |  |  |  |
 2 | 1.29 (1.09–1.53) |  |  |  |
 3 | 1.18 (0.75–1.86) |  |  |  |
Tumor location |  | < 0.001 |  | < 0.001 |
 Upper | Reference |  | Reference |  |
 Middle | 1.05 (0.83–1.33) |  | 0.92 (0.72–1.17) |  |
 Lower | 0.59 (0.48–0.73) |  | 0.79 (0.64–0.97) |  |
 Mixed | 1.56 (1.22–1.98) |  | 1.32 (1.03–1.70) |  |
Tumor size (cm) | 1.02 (1.01–1.02) | < 0.001 | 1.01 (1.00–1.01) | 0.003 |
Histologic type | Â | 0.069 | Â | Â |
 Differentiated | Reference |  |  |  |
 Undifferentiated | 1.22 (0.99–1.51) |  |  |  |
Vascular invasion |  | < 0.001 |  | 0.655 |
 Negative | Reference |  |  |  |
 Positive | 1.69 (1.41–2.02) |  |  |  |
Perineural invasion |  | < 0.001 |  | 0.885 |
 Negative | Reference |  |  |  |
 Positive | 1.63 (1.33–1.99) |  |  |  |
pTNM stage |  | < 0.001 |  | < 0.001 |
 I | Reference |  | Reference |  |
 II | 2.65 (1.82–3.68) |  | 2.00 (1.38–2.90) |  |
 III | 9.74 (7.05–13.46) |  | 6.80 (4.91–9.41) |  |
Adjuvant chemotherapy | Â | 0.260 | Â | Â |
 No | Reference |  |  |  |
 Yes | 1.10 (0.93–1.31) |  |  |  |
Hb |  | < 0.001 |  | 0.003 |
  < 125 | Reference |  | Reference |  |
  ≥ 125 | 0.51 (0.43–0.60) |  | 0.77 (0.65–0.91) |  |
LMR |  | < 0.001 |  | 0.003 |
  < 3.4 | Reference |  | Reference |  |
  ≥ 3.4 | 0.59 (0.50–0.70) |  | 0.78 (0.65–0.91) |  |
PLR |  | < 0.001 |  | 0.434 |
  < 161.3 | Reference |  |  |  |
  ≥ 161.3 | 1.70 (1.44–2.00) |  |  |  |