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Table 1 EC50 Values of AML Cells Treated with GQC-05 or Cytarabine

From: In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

Cell LineGQC-05 (nM)Cytarabine (nM)
Molm-134 ± 0.94 ± 0.9
M-07e70 ± 2924 ± 4.4
U937213 ± 10927 ± 2.9
HEL203 ± 9034 ± 4.3
Kasumi-144 ± 1460 ± 57
NB4113 ± 1765 ± 34.8
CMK157 ± 2675 ± 5
TF-1128 ± 40103 ± 26
KG-1a89 ± 30157 ± 31
CMS220 ± 48247 ± 162
AML-193321 ± 52414 ± 30
CMY104 ± 141588 ± 353
THP-1194 ± 764224 ± 564
UT-7epo76 ± 326821 ± 3880