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Table 1 EC50 Values of AML Cells Treated with GQC-05 or Cytarabine

From: In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

Cell Line

GQC-05 (nM)

Cytarabine (nM)

Molm-13

4 ± 0.9

4 ± 0.9

M-07e

70 ± 29

24 ± 4.4

U937

213 ± 109

27 ± 2.9

HEL

203 ± 90

34 ± 4.3

Kasumi-1

44 ± 14

60 ± 57

NB4

113 ± 17

65 ± 34.8

CMK

157 ± 26

75 ± 5

TF-1

128 ± 40

103 ± 26

KG-1a

89 ± 30

157 ± 31

CMS

220 ± 48

247 ± 162

AML-193

321 ± 52

414 ± 30

CMY

104 ± 14

1588 ± 353

THP-1

194 ± 76

4224 ± 564

UT-7epo

76 ± 32

6821 ± 3880