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Fig. 12 | BMC Cancer

Fig. 12

From: Elucidating the expression and function of Numbl during cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM)

Fig. 12

Numbl regulates the activation of the PI3K/AKT signaling pathway. a Myeloma adhesion model overexpressing Numbl were treated with LY294002 and the PI3K/AKT signaling pathway activation state (up) was assessed by WB, and the results of gray value quantization (down). *, # compared with the control group, P < 0.05. b Myeloma adhesion model overexpressing Numbl were treated with LY294002 and cell adhesion rate was analyzed using Calcein-AM, * compared with the control group, P < 0.05. c Myeloma adhesion model overexpressing Numbl were treated with LY294002 and different chemotherapy drugs, cell activity was evaluated. *, # compared with the control group, P < 0.05

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