Fig. 3
From: NFкB is a critical transcriptional regulator of atypical cadherin FAT1 in glioma
a Expression of FAT1 and NFкB (RelA) in glioma cell lines. Increased relative mRNA expression of FAT1 & NFкB (RelA) in U87MG, A172 and U373MG was observed. b Luciferase activity of full length 4.0 kb FAT1 promoter (pGL3F4) in glioma cell lines. Glioma cell lines (U87MG, A172 and U373MG) were transfected with pGL3F4 and pGL3B (promoterless vector). Luciferase activity was analysed by dual luciferase assay after 48 h of transfection. Significant increase in luciferase activity of pGL3F4 was found, with U87MG showing the highest luciferase activity followed by A172 and U373MG