Table 3 Relationship between clinical and pathological features of benign and malignant neoplasms of thyroid expressing NEK1, NEK3, and NEK5.* Analysis for Aperio Scan Scope slide scanner
From: Expression of the NEK family in normal and cancer tissue: an immunohistochemical study
Clinicopathological features | Nek1 Median* | p-value | Nek3 Median* | p-value | Nek5 Median* | p-value |
|---|---|---|---|---|---|---|
Gender | ||||||
Female | 172.66 | 0.4315 | 188.80 | 0.2823 | 181.08 | 0.3118 |
Male | 171.22 | 192.35 | 181.43 | |||
Age | ||||||
≤45 years old | 172.29 | 0.3894 | 188.80 | 0.2320 | 183.84 | 0.1628 |
>45 years old | 173.15 | 190.63 | 181.08 | |||
Tumor size | ||||||
<2cm | 172.29 | 0.4171 | 189.20 | 0.8575 | 180.88 | 0.0074 |
2–4cm | 169.50 | 194.40 | 174.80 | |||
>4cm | 177.83 | 185.19 | 195.24 | |||
Extrathyroidal Invasion | ||||||
Yes | 168.85 | 0.3437 | 188.41 | 0.1023 | 185.88 | 0.0424 |
No | 174.33 | 193.15 | 180.32 | |||
Capsulation | ||||||
Yes | 174.98 | 0.4361 | 194.87 | 0.0638 | 176.06 | 0.0783 |
No | 174.98 | 183.39 | 186.38 | |||
Multifocality | ||||||
Yes | 175.46 | 0.0233 | 189.25 | 0.3469 | 182.97 | 0.4222 |
No | 170.32 | 193.02 | 181.29 | |||
Metastasis at diagnosis | ||||||
Present | 175.43 | 0.3648 | 193.29 | 0.2473 | 189.71 | 0.0108 |
Absent | 173.77 | 188.85 | 179.76 | |||
Metastasis at evolution | ||||||
Present | 174.84 | 0.2053 | 196.97 | <0.0001 | 178.43 | 0.0572 |
Absent | 172.21 | 183.39 | 183.67 | |||
Lymph node metastasis | ||||||
Present | 179.22 | 0.0239 | 194.40 | 0.3475 | 184.50 | 0.0921 |
Absent | 167.63 | 197.23 | 176.05 | |||
TNM | ||||||
I | 173.81 | 0.3927 | 186.34 | 0.0023 | 181.56 | 0.8217 |
II | 168.72 | 202.86 | 174.75 | |||
III | 180.43 | 189.86 | 185.22 | |||
IV | 169.83 | 193.45 | 182.01 | |||