Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study

Table 1 Baseline characteristics of mCRC cases

	DKK1 low serum level (%)	DKK1 high serum level (%)	P
Total	28	37
Gender			0.683
Male	16 (57.1)	23 (62.2)
Female	12 (42.9)	14 (37.8)
Median age, range	56, 32~75	59, 30~76	0.454
Splenic flexure (primary tumor)			0.271
Proximal	5 (17.9)	11 (29.7)
Distal	23 (82.1)	26 (70.3)
Pathological determination			0.211
Adenocarcinoma, NOS	28 (100.0)	35 (94.6)
Mucous adenocarcinoma	0 (0.0)	2 (5.4)
R0 resection			0.278
Yes	27 (96.4)	33 (89.2)
No	1 (3.6)	4 (10.8)
Interventional therapy			0.773
Yes	26 (92.9)	35 (94.6)
No	2 (7.1)	2 (5.4)
Preoperative chemotherapy			0.190
Yes	7 (25.0)	15 (40.5)
No	21 (75.0)	22 (59.5)
Regimen of preoperative chemotherapy
XELOX	2	8
FOLFOX	2	5
FOLFIRI	3	2
Postoperative chemotherapy			0.046
Yes	12 (42.9)	25 (67.6)
No	16 (57.1)	12 (32.4)
Regimen of postoperative chemotherapy
XELODA	0	1
XELOX	9	11
FOLFOX	1	7
FOLFIRI	1	4
XELOX+XELODA	1	2
Preoperative CEA level (ng/L)			0.211
≤ 200	28 (100.0)	35 (94.6)
> 200	0 (0.0)	2 (5.4)
Primary tumor node			0.058
Positive	10 (35.7)	22 (59.5)
Negative	18 (64.3)	15 (40.5)
Disease-free interval			0.161
< 12 months	25 (89.3)	28 (75.7)
≥ 12 months	3 (10.7)	9 (24.3)
Tumor size			0.043
≤ 5 cm	28 (100.0)	32 (86.5)
> 5 cm	0 (0.0)	5 (13.5)
CRS			0.347
0	3 (10.7)	2 (5.4)
1	15 (53.6)	15 (40.5)
2	10 (35.7)	18 (48.6)
3	0 (0)	2 (5.4)

^a mCRC, metastatic colorectal cancer; NOS, not otherwise specified; CRS, clinical risk score

ISSN: 1471-2407