Fig. 3

Estimates of tumor infiltrating immune cells along with EGFR, PD-1 and PD-L1 alterations. a-d Estimates of immune cells infiltration levels according to EGFR mutation. e-h Estimates of immune cells infiltration levels according to EGFR copy-number alteration. i-j EGFR copy-number and mRNA level according to EGFR mutant LGGs. k-l PD-1 and PD-L1 were elevated in EGFR mutant LGGs. m The protein–protein interaction (PPI) network of the identified survival associated hub genes. n-p Pearson correlation analysis of PD-L1 and levels of tumor infiltrating immune cells in whole cohort. q-r Pearson correlation analysis of PD-L1 and levels of tumor infiltrating immune cells in EGFR-MUT LGGs. s-u Pearson correlation analysis of PD-L1 and levels of tumor infiltrating immune cells in EGFR-WT LGGs