Table 5 List of 20 significant ‘KEGG pathways’ that were obtained using miRNA-targeted genes in Pancreatic Cancer

1

regulation of cell proliferation (GO:0042127)

3.99E-11

BTG2;CXCL9;BMPR2;IRS1;TGFB1I1;KIF14;PTEN;ADARB1;PTPRK;CXCL13;PKD2;IGF1R;CCND2;NAMPT;TIMP1;JAK2;IL6R;PDGFRB;HGF;RPL23;AXIN2;EMP3;PPP2R5C;TGFBR1;CDC25B;KAT2B;SFRP4;BIRC5;SHC1;EIF5A2;NPR3;CDCA7;TGFA;TTK;TNFRSF11A;THBS1;TOB1;ZFP36L1;EFNB2;TBRG1;NUAK1;PAK1;GPNMB;RBBP4;FRZB;ZNF703;ABL2;HAS2;SSR1;LYN;TFAP2A;XBP1;JAG1;FN1;HMGA1;LIF;NAP1L1;KLF4;VEGFA;CUL4A;SKI;IL6;NR4A3;WT1;DLC1;ACER3;BHLHE40;CDK2;CTNNB1;CALR;FAM98A;FOLR2;IL7R;FGFR3

2

regulation of cell migration (GO:0030334)

1.97E-08

CLIC4;PLXND1;SERPINE2;ZMYND8;SERPINE1;KIF14;PTEN;PIK3CD;MIA3;PRKX;PRR5L;ADARB1;LDB2;PTPRK;RND3;THBS1;CYR61;RHOBTB1;CORO1C;IGF1R;DOCK10;PAK1;GPNMB;DPYSL3;ZNF703;FLNA;HAS2;PLXNA1;PLXNC1;PDGFRB;XBP1;ANXA1;JAG1;HGF;LAMB1;TGFBR1;SMAD7;VEGFA;DLC1;RECK

3

extracellular matrix organization (GO:0030198)

2.89E-08

ITGB4;COL12A1;ITGB2;LAMA3;SERPINE1;HTRA1;THBS1;LOXL2;SH3PXD2A;SERPINH1;HAS2;TIMP1;JAM2;POSTN;VCAM1;LAMB3;ITGA3;ITGA2;FN1;LAMB1;TGFBR1;COL1A2;COL4A2;COL5A1;LOX;COL4A1;COL4A5;COL8A1;LCP1;TGFBI;RECK;MATN3;FBN1

4

positive regulation of transcription, DNA-templated (GO:0045893)

5.06E-06

BMPR2;TGFB1I1;SERPINE1;ARRB1;AHR;IKZF1;LDB2;IKZF2;PKD2;HOXC11;LITAF;NAT14;CYR61;SIN3A;CHEK1;NAMPT;MYBL2;MEF2C;HGF;RPL23;ATRX;TCF12;WNT5A;HNF1B;RUNX2;TGFBR1;KAT2B;PLSCR1;ZEB2;CREB1;ELF4;MTF2;TET3;CKS2;ERG;ZFPM2;ATF6;HOXB7;TLR4;NFAT5;RNASEL;SHC1;PIK3R1;MRPL12;ARNTL2;DHX33;IFI16;E2F3;HIVEP3;ZNF423;MAP3K2;TFAP2A;SMAD1;SMAD4;XBP1;JAG1;SMAD3;TAF15;BCL11B;FOXF2;HMGA1;LIF;ESRRG;KLF4;TRERF1;ACVR2A;SMAD7;VEGFA;SKI;IL6;NR4A3;WT1;NFIC;POU2AF1;CAPRIN2;REL;CTNNB1;TCF4;SSBP2;PHF19

5

cytokine-mediated signaling pathway (GO:0019221)

8.46E-05

CXCL9;IRS1;ITGB2;PIK3CD;CXCL13;LMNB1;CFL1;TIMP1;JAK2;IL6R;TRIM22;IFNAR2;ANXA1;SERPINB2;RSAD2;HGF;IRAK3;ASPN;PSME4;FSCN1;BIRC5;SNRPA1;LCP1;RNASEL;SHC1;FPR1;PIK3R1;TNFRSF11A;PTGS2;TANK;SOCS3;INPP5D;CCL2;HMOX1;GBP2;FCGR1B;MCL1;SMAD4;VCAM1;FN1;LIF;PSMB8;VEGFA;IL6;COL1A2;P4HB;VIM;IL7R;BCL2L1;LIMS1

6

transforming growth factor beta receptor signaling pathway (GO:0007179)

1.14E-04

SMAD1;SMAD4;SMAD3;USP9X;ARRB2;PTPRK;TGFBR1;SKI;TGFBR3;COL1A2;ID1;ZYX;ADAM9;FERMT2

7

regulation of epithelial to mesenchymal transition (GO:0010717)

1.63E-04

SMAD4;SMAD3;TGFB1I1;PTEN;AXIN2;TGFBR1;LOXL2;PBLD;SMAD7;ZNF703;CTNNB1;PHLDB2;EZH2

8

positive regulation of cell migration (GO:0030335)

1.63E-03

PDGFRB;DOCK5;NRP1;XBP1;BMPR2;SMURF2;HGF;FN1;GAB1;PIK3CD;LAMB1;MIA3;THBS1;CYR61;RTN4;TGFBR1;IGF1R;VEGFA;PAK1;GPNMB;ZNF703;HAS2

9

cell-matrix adhesion (GO:0007160)

4.62E-03

VCAM1;ITGA3;ITGB4;DLC1;ITGA2;ITGB2;ZYX;ADAM9;HPSE;PTPRK;ADAMTS12;FERMT2

10

regulation of ERK1 and ERK2 cascade (GO:0070372)

5.09E-03

LYN;PDGFRB;EPHA4;NRP1;SMAD4;SHC1;C5AR1;FN1;PTEN;ARRB1;ARRB2;SYNJ2BP;CYR61;CTGF;IGF1R;GPNMB;GPR183;CCL2;TIMP3;FGFR3;TLR4;EPHA2

11

positive regulation of leukocyte chemotaxis (GO:0002690)

1.08E-02

CXCL9;IL6;SERPINE1;WNT5A;CALR;CXCL13;IL6R;THBS1;VEGFA

12

transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)

1.13E-02

NRP1;BMPR2;IRS1;SHC1;PIK3R1;PIK3C2A;IGF1R;EFNB2;PAK1;SPRED1;STMN1;BLNK;PDK4;ABL2;JAK2;APPL1;LYN;PDGFRB;ACTR2;EPHA4;CAV2;HGF;GAB1;AP2B1;VEGFA;DDIT4;FGFR3;CDK5R1;EPHA2

13

proteoglycan metabolic process (GO:0006029)

1.69E-02

BMPR2;CSGALNACT2;FAM20B;HPSE;ADAMTS12

14

insulin receptor signaling pathway (GO:0008286)

1.75E-02

CAV2;IRS1;SHC1;GAB1;PDK4;PIK3R1;PIK3C2A;APPL1;IGF1R

15

regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)

2.73E-02

SLC20A1;CARD8;PLK2;WNT5A;TNFAIP3;CFLAR;LITAF;TANK;MALT1;VAPA;REL;TNFSF10;FLNA;HMOX1;TRIM59;ECT2;TRIM22

16

cellular response to reactive oxygen species (GO:0034614)

3.88E-02

IL6;CDK2;PPIF;TNFAIP3;PTPRK;ECT2;PKD2;AQP1

17

inflammatory response (GO:0006954)

3.97E-02

LYN;CXCL9;ANXA1;C5AR1;ITGB2;FPR1;CXCR4;PIK3CD;TNFRSF11A;CXCL13;LYZ;THBS1;IL6;DLC1;BLNK;REL;CCL2;FOLR2;TLR4

18

positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)

4.39E-02

TLR1;THBS1;TLR4

19

protein sumoylation (GO:0016925)

4.69E-02

IFIH1;ZNF451;PCNA;NUP155;NUP50;BIRC5;RANGAP1;RAE1

20

cellular response to hypoxia (GO:0071456)

4.77E-02

BNIP3;PSME4;UBE2D3;HMOX1;PMAIP1;P4HB;PTGS2;CPEB2;PSMB8;AQP1;VEGFA;ZFP36L1