Table 3 Subgroup analyses of the included studies
Subgroup analyses | n (%) | P (95% CI) | I2 (%) | P-value | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
Sample size | ||||||||||
 ≤ 100 | 9 (75) | 0.31 (0.23–0.41) | 81.72 | < 0.001 | 0.85 (0.82–0.88) | 0.78 (0.60–0.75) | 2.72 (1.98–3.75) | 0.11 (0.32–0.40) | 26.44 (5.41–129.09) | 0.63 |
 > 100 | 3 (25) | 0.41 (0.28–0.56) | 52.94 | 0.231 | 0.69 (0.60–0.76) | 0.68 (0.66–0.71) | 2.139 (1.07–4.25) | 0.35 (0.089–1.37) | 7.03 (0.917–53.46) | 0.61 |
Ethnicity | ||||||||||
 Asian | 8 (66) | 0.32 (0.23–0.42) | 85.22 | < 0.001 | 0.91 (0.87–0.93) | 0.70 (0.66–0.72) | 3.048 (2.681–3.46) | 0.07 (0.015–0.34) | 45.42 (7.63–270.56) | 0.55 |
 Caucasian | 4 (34) | 0.38 (0.26–0.52) | 44.27 | 0.088 | 0.72 (0.67–0.77) | 0.67 (0.62–0.71) | 2.189 (1.23–3.88) | 0.29 (0.095–0.89) | 9.31 (1.73–50.1) | 0.75 |
Detection methods | ||||||||||
 PAS+ | 4 (34) | 0.40 (0.30–0.52) | 35.04 | 0.097 | 0.75 (0.69–0.81) | 0.69 (0.65–0.72) | 0.09 (0.018–0.47) | 2.98 (2.61–3.41) | 34.34 (5.12–230.22) | 0.75 |
 PAS + CD31- | 5 (41) | 0.24 (0.15–0.35) | 84.55 | < 0.001 | 0.9 (0.86–0.92) | 0.70 (0.64–0.75) | 2.36 (1.2–4.64) | 0.29 (0.073–1.17) | 9.24 (1.22–69.99) | 0.60 |
 PAS + CD34- | 3 (25) | 0.39 (0.27–0.42) | 59.52 | 0.081 | 0.73 (0.66–0.79) | 0.66 (0.59–0.72) | 2.37 (0.92–6.14) | 0.07 (0.01–37.37) | 33.43 (0.12–92.24) | 0.46 |
Total | ||||||||||
 12 (100) | 0.35 (0.27–0.42) | 79.75 | < 0.001 | 0.82 (0.79–0.84) | 0.69 (0.66–0.71) | 2.56 (1.94–3.93) | 0.17 (0.065–0.42) | 17.75 (5.301–59.44) | 0.629 | |