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Table 2 Main clinicopathological and vasculogenic mimicry characteristics of all relevant studies

From: The role of vascular mimicry as a biomarker in malignant melanoma: a systematic review and meta-analysis

First author (Ref.)

VM state n (%)

Methods of VM assay

Clark levela

Location

VM+

VM-

ІІІ

ІV

V

Head and neck

Trunk

Extremities

Maniotis AJ, [34]

106 (45)

128 (55)

PAS

–

234

–

234

–

–

Massi D, [35]

15 (30)

30 (70)

CD31/PAS

–

45

–

6

21

18

Hillen F, [37]

22 (38)

36 (78)

PAS

12

22

24

6

17

22

Zhang SH, [38]

54 (43)

70 (57)

PAS

–

65

59

16

46

62

Shi L, [39]

11 (27)

34 (73)

CD31/PAS

33

12

–

32

13

–

Beurden BV, [40]

42 (34)

81 (66)

PAS

23

51

49

–

112

11

Itzhaki O, [41]

14 (93)

1 (7)

CD31/PAS

2

8

5

2

10

3

Song H, [42]

25 (41)

37 (59)

CD31/PAS

14

45

3

62

–

–

Baocun S, [43]

10 (5)

50 (95)

CD31/PAS

–

38

22

NA

NA

NA

Zhao X, [44]

36 (45)

43 (55)

CD34/PAS

46

33

–

21

43

15

Liang X, [45]

35 (43)

46 (57)

CD34/PAS

–

41

40

34

28

19

Zhang W, [46]

106 (45)

128 (55)

CD34/PAS

–

22

30

22

16

14

  1. Abbreviations: Ref. Reference, VM Vasculogenic mimicry, PAS Periodic acid schiff’s, NA Not available
  2. aAll tissue samples are formalin-fixed, paraffin-embedded and categorized by five anatomical levels of Clark’s staging system