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Table 2 MRI features and clinical characteristics of patients with rectal cancer(n=158)

From: Characterizing MRI features of rectal cancers with different KRAS status

Factors

Total (No./values)

KRAS Status

P-value

Wild-type

(n=98)

Mutant

(n=60)

Age

60.66±13.38

60.42±12.89

61.07±14.26

0.388

Gender

   

0.769

 Male

106

66(67.35%)

40(66.67%)

 

 Female

52

32(32.65%)

20(33.33%)

 

ADC (×10-3mm2/ms )

1.22±0.39

1.37±0.37

1.15±0.38

0.008*

Texture features

 Mean

66.47±14.55

62.66±10.53

73.34±18.38

<0.0001

 Variance

289.19±118.96

267.65±122.51

334.39±94.27

<0.0001

 Skewness

0.54±0.67

0.43±0.53

0.73±0.42

<0.0001

 Entropy

1.89±0.23

1.80±0.19

1.97±0.14

<0.0001

 RLUN

178.38±65.19

159.87±53.38

208.12±69.14

<0.0001

 GLUN

7.53±3.44

6.55±2.83

9.26±3.33

<0.0001

Tumor location

 Upper Rectum

48

33(33.67%)

15(25.00%)

0.095

 Middle Rectum

72

47(47.96%)

25(41.67%)

 

 Lower Rectum

38

18(18.37%)

20(33.33%)

 

Tumor shape

   

0.022

 Intraluminal polypoid mass

40

31(31.63%)

9(15.00%)

 

 Ulcerofungating/Ulceroinfiltrative mass

95

57(58.16%)

38(63.33%)

 

 Bulky

23

10(10.20%)

13(21.67%)

 

 Tumor length(cm)

4.12±1.68

4.04±1.62

4.25±1.78

0.446*

Tumor type

   

0.556

 Mucinous adenocarcinoma

23

13(13.27%)

10(16.67%)

 

 Non-mucinous adenocarcinoma

135

85(86.73%)

50(83.33%)

 

Cirumferential extent

   

0.872**

 C1

6

4(4.08%)

2(3.33%)

 

 C2

56

36(36.73%)

20(33.33%)

 

 C3

56

34(34.69%)

22(36.67%)

 

 C4

40

24(24.49%)

16(26.67%)

 

Radiologic T stage

   

0.029

 T1-2

49

35(35.71%)

14(23.33%)

 

 T3

94

58(59.18%)

36(60.00%)

 

 T4

15

5(5.10%)

10(16.67%)

 

T3 substage

   

0.041

 T3a

23

19(32.76%)

4(11.11%)

 

 T3b

36

23(39.66%)

13(36.11%)

 

 T3c

23

11(18.97%)

12(33.33%)

 

 T3d

12

5(8.62%)

7(19.44%)

 

MEMD(cm)

0.30±0.60

0.30±0.60

0.50±0.60

0.028*

N stage

   

0.754

 N0

74

48(48.98%)

26(43.33%)

 

 N1

51

31(31.63%)

20(33.33%)

 

 N2

23

19(19.39%)

14(23.33%)

 

EMVI

   

0.664

 Positive

34

20(20.41%)

14(23.33%)

 

 Negative

124

78(79.59%)

46(76.67%)

 

CRM

   

0.337

 Positive

38

28(28.57%)

13(21.67%)

 

 Negative

120

70(71.43%)

47(78.33%)

 
  1. Abbreviations: ADC apparent diffusion coefficient, MEMD the maximal extramural depth of tumour; EMVI extramural vascular invasion, CRM circumferential resection margin, RLNU run-length nonuniformity, GLNU grey-level nonuniformity
  2. *independent samples t test, data is mean ± standard deviation;Δ Mann-Whitney U test, data is data is median ± interquartile range. **Considering limited patients’ numbers in subgroups of circumferential extent, reclassification was adopted as follows: C1-2, C3, and C4, and P value was the result of new categorization