Table 5 Comparison between groups with favorable MCS (scores > 50) and unfavorable MCS (scores ≤ 50) HRQoL at M24
Favorable MCS (scores > 50) n = 165 | Unfavorable MCS (scores ≤50) n = 33 | OR CI 95% | P-Value Univariate | |
|---|---|---|---|---|
Gender | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
Men | 86 (81.1%) | 20 (18.9%) | 1.413 [0.659,3.028] | 0.3738 |
Women (Réf.) | 79 (85.9%) | 13 (14.1%) | ||
Age (years) at AMA-AC entry | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
Mean (s.d.) | 54.9 (15.8) | 57.3 (13.9) | 1.111 [0.865,1.427] | 0.4095 |
Level of education | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
Higher education status (> high school degree) (Réf.) | 77 (89.5%) | 9 (10.5%) | ||
Lower education status (<= high school degree) | 88 (78.6%) | 24 (21.4%) | 2.333 [1.023,5.324] | 0.0441 |
Cohabitation status | ||||
N | 161 | 28 | ||
Missing | 4 | 5 | ||
Living alone (single, divorced, widowed) (Réf.) | 42 (87.5%) | 6 (12.5%) | ||
Living together (married, living in partnership) | 119 (84.4%) | 22 (15.6%) | 1.294 [0.491,3.409] | 0.6020 |
Occupational status | ||||
N | 161 | 28 | ||
Missing | 4 | 5 | ||
Active (employed) (Réf.) | 82 (84.5%) | 15 (15.5%) | ||
Not active (unemployed, retired, jobless) | 79 (85.9%) | 13 (14.1%) | 0.900 [0.402,2.011] | 0.7965 |
Geographical area | ||||
N | 161 | 28 | ||
Missing | 4 | 5 | ||
Rural (Réf.) | 76 (86.4%) | 12 (13.6%) | ||
Urban/Semi-urban | 85 (84.2%) | 16 (15.8%) | 1.192 [0.530,2.680] | 0.6706 |
Histology | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
Diffuse large B-cell lymphoma (DLBCL) (Réf.) | 110 (87.3%) | 16 (12.7%) | ||
Others (FL, HL, MCL) | 55 (76.4%) | 17 (23.6%) | 2.125 [0.998,4.524] | 0.0505 |
Stage in class | ||||
N | 164 | 33 | ||
Missing | 1 | 0 | ||
I / II (Réf.) | 36 (81.8%) | 8 (18.2%) | ||
III / IV | 128 (83.7%) | 25 (16.3%) | 0.879 [0.365,2.114] | 0.7732 |
ECOG in class | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
≤ 1 (Réf.) | 148 (84.6%) | 27 (15.4%) | ||
≥ 2 | 17 (73.9%) | 6 (26.1%) | 1.935 [0.700,5.349] | 0.2035 |
CHARLSON SCORE (class) | ||||
N | 117 | 27 | ||
Missing | 48 | 6 | ||
1 (Réf.) | 25 (71.4%) | 10 (28.6%) | ||
> =2 | 92 (84.4%) | 17 (15.6%) | 0.462 [0.188,1.133] | 0.0917 |
Type of treatment | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
Conventional | 115 (83.3%) | 23 (16.7%) | 1.000 [0.443,2.255] | 1.0000 |
Intensified (Réf.) | 50 (83.3%) | 10 (16.7%) | ||
Calculated BMI (kg/m2) | ||||
N | 160 | 28 | ||
Missing | 5 | 5 | ||
Mean (s.d.) | 24.1 (4.0) | 24.6 (4.9) | 1.023 [0.932,1.123] | 0.6298 |
Physical Components Summary scale (class) at M12 | ||||
N | 165 | 32 | ||
Missing | 0 | 1 | ||
Unfavorable (≤50) | 19 (46.3%) | 22 (53.7%) | 16.905 [6.961,41.054] | <.0001 |
Favorable (> 50) (Réf.) | 146 (93.6%) | 10 (6.4%) | ||
Mental Components Summary scale (class) at M12 | ||||
N | 165 | 32 | ||
Missing | 0 | 1 | ||
Unfavorable (≤50) | 19 (47.5%) | 21 (52.5%) | 14.670 [6.133,35.091] | <.0001 |
Favorable (> 50) (Réf.) | 146 (93.0%) | 11 (7.0%) | ||
At least one occurrence of depression between 3 and 18 months (HAD depression scores > 8) | ||||
N | 164 | 33 | ||
Missing | 1 | 0 | ||
No (Réf.) | 128 (88.9%) | 16 (11.1%) | ||
Yes | 36 (67.9%) | 17 (32.1%) | 3.778 [1.738,8.211] | 0.0008 |
At least one occurrence of anxiety between 3 and 18 months (HAD anxiety scale > 8) | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
No (Réf.) | 107 (89.2%) | 13 (10.8%) | ||
Yesi | 58 (74.4%) | 20 (25.6%) | 2.838 [1.317,6.117] | 0.0078 |
At least one occurrence of anxiety between 3 and 18 months (HAD-anxiety scale > 8) | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
No (Réf.) | 107 (89.2%) | 13 (10.8%) | ||
Yesi | 58 (74.4%) | 20 (25.6%) | 2.838 [1.317,6.117] | 0.0078 |
At least one occurrence of PTSD between 3 and 18 months | ||||
N | 161 | 32 | ||
Missing | 4 | 1 | ||
No (Réf.) | 142 (90.4%) | 15 (9.6%) | ||
Yes | 19 (52.8%) | 17 (47.2%) | 8.471 [3.645,19.688] | <.0001 |
At least one occurrence of cardiovascular disorders between 3 and 18 months | ||||
N | 164 | 33 | ||
Missing | 1 | 0 | ||
No (Réf.) | 142 (85.5%) | 24 (14.5%) | ||
Yes | 22 (71.0%) | 9 (29.0%) | 2.420 [0.996,5.882] | 0.0511 |
At least one infection occurring between 3 and 18 months | ||||
N | 164 | 33 | ||
Missing | 1 | 0 | ||
No (Réf.) | 41 (83.7%) | 8 (16.3%) | ||
Yes | 123 (83.1%) | 25 (16.9%) | 1.041 [0.436,2.488] | 0.9273 |
At least one occurrence of arthralgia between 3 and 18 months | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
No (Réf.) | 51 (85.0%) | 9 (15.0%) | ||
Yes | 114 (82.6%) | 24 (17.4%) | 1.193 [0.518,2.747] | 0.6785 |
At least one occurrence of neuropathy between 3 and 18 months | ||||
N | 165 | 33 | ||
Missing | 0 | 0 | ||
No (Réf.) | 108 (85.7%) | 18 (14.3%) | ||
Yes | 57 (79.2%) | 15 (20.8%) | 1.579 [0.741,3.365] | 0.2366 |