Table 3 Comparison between groups with favorable (PCS scores > 50) and unfavorable (PCS scores ≤50) HRQoL at M24
Favorable PCS (scores > 50) n = 164 | Unfavorable PCS (scores ≤50) n = 34 | OR CI 95% | P-Value Univariate | |
|---|---|---|---|---|
Gender | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
Men | 90 (84.9%) | 16 (15.1%) | 0.731 [0.349,1.532] | 0.4065 |
Women (Réf.) | 74 (80.4%) | 18 (19.6%) | ||
Age (years) at AMA-AC entry | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | Unit = 10 | |
Mean (s.d.) | 53.8 (15.7) | 62.4 (12.0) | 1.531 [1.144,2.050] | 0.0042 |
Level of education | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
Higher education status (> high school degree) (Réf.) | 77 (89.5%) | 9 (10.5%) | ||
Lower education status (≤ high school degree) | 87 (77.7%) | 25 (22.3%) | 2.458 [1.081,5.589] | 0.0318 |
Cohabitation status | ||||
N | 159 | 30 | ||
Missing | 5 | 4 | ||
Living alone (single, divorced, widowed) (Réf.) | 43 (89.6%) | 5 (10.4%) | ||
Living together (married, living in partnership) | 116 (82.3%) | 25 (17.7%) | 1.853 [0.667,5.150] | 0.2367 |
Occupational status | ||||
N | 159 | 30 | ||
Missing | 5 | 4 | ||
Active (employed) (Réf.) | 87 (89.7%) | 10 (10.3%) | ||
Not active (unemployed, retired, jobless) | 72 (78.3%) | 20 (21.7%) | 2.417 [1.064,5.491] | 0.0351 |
Geographical area | ||||
N | 159 | 30 | ||
Missing | 5 | 4 | ||
Rural (Réf.) | 76 (86.4%) | 12 (13.6%) | ||
Urban/Semi-urban | 83 (82.2%) | 18 (17.8%) | 1.373 [0.621,3.038] | 0.4334 |
Histology | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
Diffuse large B-cell lymphoma (DLBCL) (Réf.) | 104 (82.5%) | 22 (17.5%) | ||
Others (FL, HL, MCL) | 60 (83.3%) | 12 (16.7%) | 0.945 [0.437,2.046] | 0.8867 |
Stage in class | ||||
N | 163 | 34 | ||
Missing | 1 | 0 | ||
I / II (Réf.) | 36 (81.8%) | 8 (18.2%) | ||
III / IV | 127 (83.0%) | 26 (17.0%) | 0.921 [0.384,2.209] | 0.8542 |
ECOG in class | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
≤ 1 (Réf.) | 146 (83.4%) | 29 (16.6%) | ||
≥ 2 | 18 (78.3%) | 5 (21.7%) | 1.399 [0.481,4.069] | 0.5379 |
CHARLSON SCORE (class) | ||||
N | 113 | 31 | ||
Missing | 51 | 3 | ||
1 (Réf.) | 27 (77.1%) | 8 (22.9%) | ||
≥ 2 | 86 (78.9%) | 23 (21.1%) | 0.903 [0.362,2.250] | 0.8260 |
Type of treatment | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
Conventional | 112 (81.2%) | 26 (18.8%) | 1.508 [0.640,3.557] | 0.3476 |
Intensified (Réf.) | 52 (86.7%) | 8 (13.3%) | ||
Calculated BMI (kg/m2) | ||||
N | 158 | 30 | ||
Missing | 6 | 4 | ||
Mean (s.d.) | 24.1 (4.0) | 24.7 (5.1) | 1.033 [0.945,1.130] | 0.4730 |
Physical Components Summary scale (class) at M12 | ||||
N | 164 | 33 | ||
Missing | 0 | 1 | ||
Unfavorable (≤50) | 21 (51.2%) | 20 (48.8%) | 10.476 [4.545,24.147] | <.0001 |
Favorable (> 50) (Réf.) | 143 (91.7%) | 13 (8.3%) | ||
Mental Components Summary scale (class) at M12 | ||||
N | 164 | 33 | ||
Missing | 0 | 1 | ||
Unfavorable (≤50) | 23 (57.5%) | 17 (42.5%) | 6.514 [2.890,14.680] | <.0001 |
Favorable (> 50) (Réf.) | 141 (89.8%) | 16 (10.2%) | ||
At least one occurrence of depression between 3 and 18 months (HAD depression scale > 8) | ||||
N | 163 | 34 | ||
Missing | 1 | 0 | ||
No (Réf.) | 125 (86.8%) | 19 (13.2%) | ||
Yes | 38 (71.7%) | 15 (28.3%) | 2.597 [1.205,5.599] | 0.0149 |
At least one occurrence of anxiety between 3 and 18 months (HAD anxiety scale > 8) | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
No (Réf.) | 101 (84.2%) | 19 (15.8%) | ||
Yes | 63 (80.8%) | 15 (19.2%) | 1.266 [0.600,2.670] | 0.5362 |
At least one occurrence of PTSD between 3 and 18 months | ||||
N | 161 | 32 | ||
Missing | 3 | 2 | ||
No (Réf.) | 140 (89.2%) | 17 (10.8%) | ||
Yes | 21 (58.3%) | 15 (41.7%) | 5.882 [2.560,13.519] | <.0001 |
At least one occurrence of cardiovascular disorders between 3 and 18 months | ||||
N | 163 | 34 | ||
Missing | 1 | 0 | ||
No (Réf.) | 143 (86.1%) | 23 (13.9%) | ||
Yes | 20 (64.5%) | 11 (35.5%) | 3.420 [1.451,8.060] | 0.0049 |
At least one infection occurring between 3 and 18 months | ||||
N | 163 | 34 | ||
Missing | 1 | 0 | ||
No (Réf.) | 40 (81.6%) | 9 (18.4%) | ||
Yes | 123 (83.1%) | 25 (16.9%) | 0.903 [0.389,2.095] | 0.8128 |
At least one occurrence of arthralgia between 3 and 18 months | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
No (Réf.) | 54 (90.0%) | 6 (10.0%) | ||
Yes | 110 (79.7%) | 28 (20.3%) | 2.291 [0.895,5.864] | 0.0839 |
At least one occurrence of neuropathy between 3 and 18 months | ||||
N | 164 | 34 | ||
Missing | 0 | 0 | ||
No (Réf.) | 110 (87.3%) | 16 (12.7%) | ||
Yes | 54 (75.0%) | 18 (25.0%) | 2.292 [1.085,4.842] | 0.0298 |