The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis

Table 3 Meta-analysis of the association between rs2057482 polymorphism and cancer susceptibility

Subgroup	No.	T vs. C			TT vs. CC			CT vs. CC			TT + CT vs. CC			TT vs. CT + CC
Subgroup	No.	OR(95%Cl)	P_OR	I²	OR(95%Cl)	P_OR	I²	OR(95%Cl)	P_OR	I²	OR(95%Cl)	P_OR	I²	OR(95%Cl)	P_OR	I²
Overall	7	0.93(0.86–1.01)	0.081	4.4%	1.01(0.82–1.26)	0.903	0.0%	0.85(0.71–1.03)^*	0.091	66.8%	0.89(0.81–0.98)	0.017	45.6%	1.08(0.87–1.33)	0.502	3.6%
Asian	5	0.93(0.85–1.01)	0.070	28.8%	1.01(0.81–1.26)	0.943	0.2%	0.82(0.65–1.04)^*	0.096	77.2%	0.87(0.73–1.03)^*	0.095	61.8%	1.08(0.86–1.34)	0.526	23.4%

OR, odds ratio; 95% CI, 95% confidence interval; P_OR, pool P value; RCC, renal cell carcinoma; *indicates that the OR, 95% Cl, and corresponding P_OR were calculated based on the random-effects model; otherwise, the fixed-effects model was used. Bold values are statistically significant (P_OR < 0.05)

ISSN: 1471-2407