Fig. 2
Topological properties of the ovarian cancer network. a. The behaviours of degree distributions (P(k), clustering co-efficient (C(k)), neighbourhood connectivity (CN(k)), betweenness (CB(k)), closeness (CC(k)) and eigen-vector (CE(k)) measurements as a function of degree k for original and five key regulators knock-out network at different levels of organization. b. The changes in the exponents of the six topological parameters due to key regulators knock-out experiment. c. Energy distribution in the network quantified by Hamiltonian calculation as a function of network levels. d. Changes in the network modules/sub-modules due to five key regulators knock-out experiment. The dotted modules/sub-modules are the break-down modules/sub-modules