Fig. 5
From: Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation
NPC cells show increased Lapatinib sensitivity when combined with AGK2 or AK1 but not Sirtinol or Ex527. a Cells (3 × 103 / well) were seeded in 96-well plates and treated with increasing concentrations of Lapatinib for 48 h before staining and measurement of optical density at 492 nm. Data were analysed by generating curves using Graph-pad Prism. b Best-fit curves were generated to determine the effect of AGK2 or AK1 on reducing the IC50 of Lapatinib for each NPC cells. Data represent the average ± SEM of three different experiments (**** P < 0.0001)