Table 3 Histologic types and molecular features of CK7 negative and GATA3 negative breast cancers
Histologic type and molecular features | CK7 negative | CK7 positive | P-value | GATA3 negative | GATA3 positive | P-value |
|---|---|---|---|---|---|---|
Ductal | 0.7565 | <0.001 | ||||
Grade 3 | 22 (13%) | 147 (87%) | 47 (27%) | 126 (73%) | ||
Grade 1 & Grade 2 | 11 (12%) | 83 (88%) | 6 (6%) | 91 (94%) | ||
Lobular & Mixed | ||||||
Grade 3 | 0 | 37 | 0 | 36 | ||
Grade 1-Grade 2 | 0 | 18 | 0 | 20 | ||
Metaplastic (all Grade 3) | 3 (30%) | 7 (70%) | 7 (70%) | 3 (30%) | ||
Cribriform (all Grade 1-Grade 2) | 0 | 5 | 0 | 6 | ||
Micropapillary (all Grade 1-Grade 2) | 0 | 4 | 0 | 4 | ||
Mucinous (all Grade 1-Grade 2) | 0 | 5 | 0 | 5 | ||
Tubular (all Grade 1-Grade 2) | 0 | 3 | 0 | 3 | ||
Apocrine (Grade 2) | 0 | 1 | 1 | 0 | ||
ER (Grade 3 only) | 0.2822 | <0.0001 | ||||
Positive | 14 (16%) | 72 (84%) | 2 (2%) | 89 (98%) | ||
Negative | 11 (10%) | 95 (90%) | 52 (50%) | 52 (50%) | ||
PR (Grade 3 only) | 0.0270 | <0.0001 | ||||
Positive | 15 (20%) | 61 (80%) | 5 (6%) | 74 (94%) | ||
Negative | 10 (9%) | 106 (91%) | 49 (42%) | 67 (58%) | ||
Her2 (Grade 3 only) | 0.9434 | 0.0826 | ||||
Positive | 6 (13%) | 39 (87%) | 9 (18%) | 40 (82%) | ||
Negative | 19 (13%) | 128 (87%) | 45 (31%) | 101 (69%) | ||
Subtype (Grade 3 only) | 0.6154 | <0.0001 | ||||
Luminal | 10 (16%) | 76 (89%) | 1 (2%) | 63 (98%) | ||
Her2 | 6 (13%) | 39 (87%) | 9 (18%) | 40 (82%) | ||
Basal-like | 9 (11%) | 76 (90%) | 44 (54%) | 38 (46%) | ||