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Table 3 Histologic types and molecular features of CK7 negative and GATA3 negative breast cancers

From: Cytokeratin 7-negative and GATA binding protein 3-negative breast cancers: Clinicopathological features and prognostic significance

Histologic type and molecular featuresCK7 negativeCK7 positiveP-valueGATA3 negativeGATA3 positiveP-value
Ductal  0.7565  <0.001
 Grade 322 (13%)147 (87%) 47 (27%)126 (73%) 
 Grade 1 & Grade 211 (12%)83 (88%) 6 (6%)91 (94%) 
Lobular & Mixed
 Grade 3037 036 
 Grade 1-Grade 2018 020 
Metaplastic (all Grade 3)3 (30%)7 (70%) 7 (70%)3 (30%) 
Cribriform (all Grade 1-Grade 2)05 06 
Micropapillary (all Grade 1-Grade 2)04 04 
Mucinous (all Grade 1-Grade 2)05 05 
Tubular (all Grade 1-Grade 2)03 03 
Apocrine (Grade 2)01 10 
ER (Grade 3 only)  0.2822  <0.0001
 Positive14 (16%)72 (84%) 2 (2%)89 (98%) 
 Negative11 (10%)95 (90%) 52 (50%)52 (50%) 
PR (Grade 3 only)  0.0270  <0.0001
 Positive15 (20%)61 (80%) 5 (6%)74 (94%) 
 Negative10 (9%)106 (91%) 49 (42%)67 (58%) 
Her2 (Grade 3 only)  0.9434  0.0826
 Positive6 (13%)39 (87%) 9 (18%)40 (82%) 
 Negative19 (13%)128 (87%) 45 (31%)101 (69%) 
Subtype (Grade 3 only)  0.6154  <0.0001
 Luminal10 (16%)76 (89%) 1 (2%)63 (98%) 
 Her26 (13%)39 (87%) 9 (18%)40 (82%) 
 Basal-like9 (11%)76 (90%) 44 (54%)38 (46%)