Table 3 This table shows genes that are differentially regulated when comparing the cisplatin-resistant versus cisplatin-sensitive TNBC subtypes. Column 2 is a brief note about the action of the gene. Column 3 is a representative reference supporting the mechanism

ABCC2 (up in LAR)

A transporter that when overexpressed results in cisplatin resistance

[42]

AKT1 (up in LAR)

A stress-response protein that when amplified or overexpressed is correlated with cisplatin resistance

[43, 44]

BCL2L1 (up in LAR)

Apoptosis-inhibitor, overexpression correlates with cisplatin resistance

[45, 46]

CASP8 (up in LAR down in M)

Required for cisplatin-associated apoptosis

[47, 48]

CLU (up in LAR)

Well known to contribute to chemoresistance including cisplatin

[49, 50]

FAS (down in M)

Overexpression induces cisplatin sensitivity and reduced expression correlates with resistance

[51,52,53]

GSR (up in LAR)

Involved in the detoxification of cisplatin

[54, 55]

MSH2 (down in LAR)

Required for cisplatin induced apoptosis

[56,57,58]

NOX4 (up in M)

Increased expression leads to more severe cisplatin toxicity

[37]

NQO1 (up in LAR)

A redox enzyme that has been show to contribute to resistance to cisplatin toxicity

[59,60,61]

TUBA1A (up in M down in LAR)

Correlated with cisplatin-reistance in esophageal cells

[62]

VCAM1 (down in M)

Associated with epithelial to mesenchymal transition overexpression contributes to cisplatin resistance

[63]

VIM (up in M down in LAR)

Associated with epithelial to mesenchymal transition

[64, 65]