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Table 3 This table shows genes that are differentially regulated when comparing the cisplatin-resistant versus cisplatin-sensitive TNBC subtypes. Column 2 is a brief note about the action of the gene. Column 3 is a representative reference supporting the mechanism

From: Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance

Gene Symbol Evidence for Resistance Reference
ABCC2 (up in LAR) A transporter that when overexpressed results in cisplatin resistance [42]
AKT1 (up in LAR) A stress-response protein that when amplified or overexpressed is correlated with cisplatin resistance [43, 44]
BCL2L1 (up in LAR) Apoptosis-inhibitor, overexpression correlates with cisplatin resistance [45, 46]
CASP8 (up in LAR down in M) Required for cisplatin-associated apoptosis [47, 48]
CLU (up in LAR) Well known to contribute to chemoresistance including cisplatin [49, 50]
FAS (down in M) Overexpression induces cisplatin sensitivity and reduced expression correlates with resistance [51,52,53]
GSR (up in LAR) Involved in the detoxification of cisplatin [54, 55]
MSH2 (down in LAR) Required for cisplatin induced apoptosis [56,57,58]
NOX4 (up in M) Increased expression leads to more severe cisplatin toxicity [37]
NQO1 (up in LAR) A redox enzyme that has been show to contribute to resistance to cisplatin toxicity [59,60,61]
TUBA1A (up in M down in LAR) Correlated with cisplatin-reistance in esophageal cells [62]
VCAM1 (down in M) Associated with epithelial to mesenchymal transition overexpression contributes to cisplatin resistance [63]
VIM (up in M down in LAR) Associated with epithelial to mesenchymal transition [64, 65]