From: Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance
Gene Symbol | Evidence for Resistance | Reference |
---|---|---|
ABCC2 (up in LAR) | A transporter that when overexpressed results in cisplatin resistance | [42] |
AKT1 (up in LAR) | A stress-response protein that when amplified or overexpressed is correlated with cisplatin resistance | |
BCL2L1 (up in LAR) | Apoptosis-inhibitor, overexpression correlates with cisplatin resistance | |
CASP8 (up in LAR down in M) | Required for cisplatin-associated apoptosis | |
CLU (up in LAR) | Well known to contribute to chemoresistance including cisplatin | |
FAS (down in M) | Overexpression induces cisplatin sensitivity and reduced expression correlates with resistance | |
GSR (up in LAR) | Involved in the detoxification of cisplatin | |
MSH2 (down in LAR) | Required for cisplatin induced apoptosis | |
NOX4 (up in M) | Increased expression leads to more severe cisplatin toxicity | [37] |
NQO1 (up in LAR) | A redox enzyme that has been show to contribute to resistance to cisplatin toxicity | |
TUBA1A (up in M down in LAR) | Correlated with cisplatin-reistance in esophageal cells | [62] |
VCAM1 (down in M) | Associated with epithelial to mesenchymal transition overexpression contributes to cisplatin resistance | [63] |
VIM (up in M down in LAR) | Associated with epithelial to mesenchymal transition |