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Table 2 Number and type of malignancies among individuals of the hereditary breast/ovarian cancer (HBOC) study

From: Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)

  TotalHBOC study
High risk BRCA1+
n (%)
High risk BRCA2+
n (%)
High risk BRCA-
n (%)
Low risk
n (%)
Navarra Cancer RegistryPatients with one or more tumors
 Single tumor506 (85.3%)33 (78.6%)47 (78.3%)303 (86.1%)123 (88.5%)
 Multiple tumors (a)87 (14.7%)9 (21.4%)13 (21.7%)49 (13.9%)16 (11.5%)
Total5934260352139
(a) BRCA1/2 vs Low Risk: OR = 2.11 95%CI = 1.04 to 4.33, p-value = 0.038
Tumors by affected tissue
 BREAST531 (76.6%)30 (55.6%)53 (70.7%)327 (80.5%)120 (76.4%)
 OVARY55 (7.9%)13 (24.1%)7 (9.3%)27 (6.6%)8 (5.1%)
 SKIN46 (6.6%)6 (11.1%)4 (5.3%)24 (5.9%)12 (7.6%)
 ENDOMETRIUM13 (1.9%)1 (1.8%)2 (2.7%)7 (1.7%)3 (1.9%)
 PANCREAS5 (0.7%)2 (3.7%)003 (1.9%)
 COLON5 (0.7%)01 (1.3%)4 (1%)0
 PROSTATE GLAND3 (0.4%)02 (2.7%)01 (0.6%)
 OTHERS35 (5.1%)2 (3.7%)6 (8%)17 (4.2%)10 (6.4%)
TOTAL6935475406157