Fig. 5

Depicted are tumor-proliferative fractions (I), tumor-apoptotic fractions (II), tumor (III), necrosis (IV) and stroma (V) fractions of Ki-67, Casp3 and morphometric analysis across all nine patients in Box-Jitter plots. The mean-values of each patient are depicted as a black dot. Statistical differences were calculated using the Mann-Whitney U test and are marked (* p value ≤0.05; ** p value ≤0.01). a- control; b- Oxaliplatin 20 μM; c- Oxaliplatin 5 μM; d- Cetuximab 200 nM; e- Cetuximab 20 nM; f- Pembrolizumab 1400 nM; g- Pembrolizumab 140 nM