Fig. 1
Over-expressed androgen receptor inhibits E2-dependent MCF-7 cells proliferation. MCF-7 cells and and MCF-7 transiently over-expressing AR (MCF-7/AR), were synchronized in PRF and treated with 10− 7 M E2, and/or 10− 7 M DHT, and/or 10− 6 M OH-Fl in steroids depleted PRF-CT for 3 days. Data represent a mean ± s.d. of three independent experiments, each in duplicate. *p ≤ 0.05 vs untreated MCF-7 cells; □p ≤ 0.05 vs. E2-treated MCF-7 cells; ●p ≤ 0.05 vs E2 + DHT treated MCF-7 cells; ▲p ≤ 0.05 vs E2 + DHT treated MCF-7/AR