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Table 4 Univariate cox regression analysis of DFS

From: Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy

 

Disease-free survival

Parameter

HR

95% CI

P

Age

1.03

[0.99; 1.06]

0.124

Male vs. female

0.63

[0.32; 1.24]

0.177

BMI

0.91

[0.85; 0.98]

0.009

ASA 2 and 3

2.04

[0.62; 6.66]

0.238

cM1

7.58

[3.42; 16.79]

<  0.001

Type of resection: APR vs. LAR

1.83

[0.92; 3.62]

0.083

Adjuvant therapy recieved

0.99

[0.44; 2.21]

0.979

Tumor size

1.02

[1.00; 1.04]

0.048

CRM

0.93

[0.88; 0.97]

0.002

Poor Quirke Grade

1.78

[0.99; 3.18]

0.053

Higher ypT stage [ypT3–4]

4.20

[1.83; 9.66]

0.001

ypN+

2.34

[1.16; 4.68]

0.017

Histological Grading

1.97

[1.20; 3.25]

0.008

Tumor regression Grading

0.35

[0.16; 0.75]

0.007

Budding positive H&E

3.54

[1.82; 6.89]

<  0.001

Budding positive IHC

6.23

[2.57; 15.31]

<  0.001

V1

2.41

[1.16; 5.03]

0.019

L1

2.75

[1.20; 6.32]

0.017

Pn1

5.49

[2.65; 11.37]

0.001

R+

1.51

[0.36; 6.35]

0.573

  1. Abbreviations: DFS disease-free survival, HR hazard ratio, 95% CI 95% confidence interval, P P-value, BMI body mass index, ASA American Society of Anesthesiologists, APR abdominoperineal excision, LAR low anterior resection, CRM circumferential resection margin, Pn1 perineural invasion; R+ = invaded margin. Significant p-values and corresponding hazard ratios are represented in bold type
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BMC Cancer

ISSN: 1471-2407

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