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Table 4 Multiple hypothesis testing of factors associated with survival

From: The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy

Breast cancer subtypes RFS OS DMFS
HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
ER status
 ER+ 1.85 1.57–2.18 < 0.001 2.61 1.86–3.68 < 0.001 2.92 2.09–4.07 < 0.001
 ER- 1.18 0.9–1.18 0.23 1.24 0.8–1.92 0.34 1.4 0.9–2.17 0.13
PR status
 PR+ 3.4 2.09–5.55 < 0.001 6.34 1.26–31.88 ns, 0.011 3.92 1.15–13.32 ns, 0.018
 PR- 1.51 1.11–2.05 ns, 0.0081 2.79 0.99–7.82 ns, 0.042 3.39 1.88–6.11 < 0.001
HER2 status
 HER2+ 1.73 1.17–2.56 ns, 0.0053 3.42 1.52–7.72 0.0017 1.78 0.94–3.39 ns, 0.073
 HER2- 2.12 1.79–2.51 < 0.001 1.7 1.37–2.12 < 0.001 1.93 1.58–2.36 < 0.001
Lymph node status
 Lymph node+ 2.19 1.67–2.88 < 0.001 1.72 1.18–2.5 ns, 0.0044 2.03 1.4–2.94 < 0.001
 Lymph node- 1.82 1.52–2.17 < 0.001 3 1.88–4.78 < 0.001 2.39 1.8–3.19 < 0.001
Grade
 1 3.12 1.8–5.42 < 0.001 3.19 1.28–7.96 ns, 0.0087 2.79 1.23–6.33 ns, 0.011
 2 1.99 1.56–2.55 < 0.001 2.55 1.67–3.89 < 0.001 2.61 1.85–3.68 < 0.001
 3 1.35 1.07–1.7 ns, 0.011 1.25 0.89–1.77 0.19 1.75 1.13–2.73 ns, 0.012
TP53 status
 Mutated 0.77 0.48–1.26 0.3 0.69 0.34–1.42 0.32 0.56 0.26–1.22 0.14
 Wild type 1.82 1.16–2.85 ns, 0.0077 2.56 1.38–4.76 0.0021 3.67 1.76–7.63 < 0.001
  1. ns Not significant after correction for multiple hypothesis testing; bold faced: remained significant