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Table 1 PH Cox regression univariate analyses for the association of gene SPAG5 with cancer progression and prognosis in different breast cancer subtypes

From: The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy

Breast cancer subtypes RFS OS DMFS
n HR P-value n HR P-value n HR P-value
Total 3557 1.72 (1.54–1.94) < 0.001 1117 1.86 (1.46–2.37) < 0.001 1610 1.88 (1.53–2.32) < 0.001
ER status
 ER+ 2766 1.77 (1.55–2.03) < 0.001 377 2.74 (1.74–4.33) < 0.001 577 2.89 (1.95–4.29) < 0.001
 ER- 788 1.03 (0.82–1.28) 0.81 142 0.91 (0.52–1.6) 0.74 170 1.04 (0.62–1.73) 0.89
PR status
 PR+ 525 2.02 (1.38–2.94) < 0.001 0 122 1.35 (0.41–4.46) 0.62
 PR- 483 1.42 (1.04–1.93) 0.027 2 95 2.24 (1.04–4.85) 0.035
HER2 status
 HER2+ 168 0.78 (0.46–1.32) 0.36 28 0.59 (0.19–1.83) 0.36 66 1.54 (0.61–3.91) 0.36
 HER2- 756 1.78 (1.36–2.34) < 0.001 62 0.92 (0.32–2.62) 0.87 82 2.43 (0.63–9.39) 0.18
ER+/PR+/HER2+ 76 1.53 (0.33–7.09) 0.58 36 3.54 (0.41–30.58) 0.22 45 1.83 (0.36–9.47) 0.46
ER+/PR−/HER2+ 26 0.47 (0.09–2.35) 0.35
ER+/PR+/HER2- 339 2.41 (1.48–3.93) < 0.001 39 2.04 (0.18–22.51) 0.55 79 1.66 (0.33–8.22) 0.53
ER+/PR−/HER2- 77 1.47 (0.65–3.33) 0.35
ER−/PR−/HER2- 255 1.45 (0.9–2.34) 0.13 43 3.33 (0.67–16.58) 0.12
LN status
 LN+ 945 1.63 (1.3–2.03) < 0.001 197 1.38 (0.84–2.28) 0.2 337 1.74 (1.14–2.65) 0.009
 LN- 1813 1.67 (1.4–1.99) < 0.001 425 2.41 (1.56–3.74) < 0.001 896 2.42 (1.79–3.27) < 0.001
Grade
 1 308 2.52 (1.4–4.54) 0.0014 135 2.45 (0.86–6.96) 0.083 172 2.35 (0.94–5.84) 0.059
 2 724 1.9 (1.45–2.49) < 0.001 287 2.92 (1.76–4.86) < 0.001 495 1.93 (1.34–2.78) < 0.001
 3 723 1.17 (0.91–1.51) 0.23 347 0.9 (0.6–1.34) 0.6 391 1.12 (0.77–1.64) 0.54
TP53 status
 Mutated 188 0.91 (0.57–1.47) 0.71 111 0.95 (0.45–2.04) 0.91 83 0.8 (0.33–1.93) 0.62
 Wild type 273 1.49 (0.97–2.28) 0.064 187 2.16 (1.1–4.23) 0.022 109 3.44 (1.44–8.22) 0.0031
  1. RFS Relapse free survival, OS Overall survival, DMFS Distant metastasis-free survival, HR Hazard ratio, − Ddata not available, LN Lymph node