Table 4 Univariate and multivariate analysis for the colorectal-specific overall survival of histologic subtypes in colorectal cancer

Sex

0.06

 Male

 Female

Age (yrs)

<  0.001

2.26

1.87–2.73

<  0.001

  ≤ 66

  > 66

Tumor location

<  0.001

 Colon

 Rectum

Grade

<  0.001

0.001

 Well differentiated

1

Reference

 Moderately differentiated

1.50

0.96–2.34

0.08

 Poorly differentiated or undifferentiated

2.06

1.30–3.28

0.002

TNM stage

<  0.001

<  0.001

 0 + I

1

Reference

 II

2.04

1.24–3.35

0.01

 III

5.12

3.23–8.09

<  0.001

 IV

15.39

9.55–24.79

<  0.001

Race

<  0.001

 American Indian/Alaska Native

 Asian or Pacific Islander

 Black

 White

Insurance status

<  0.001

 Insured

 Others

Marital status

<  0.001

0.003

 Married

1

Reference

 Widowed

1.40

1.10–1.78

0.01

 Others

1.33

1.08–1.63

0.01

CEA

<  0.001

<  0.001

 Normal

1

Reference

 Borderline

1.43

0.45–4.51

0.54

 Elevated

1.76

1.44–2.15

<  0.001

CRM

<  0.001

1.47

1.22–1.77

<  0.001

 Negative

 Positive

Perineural invasion

<  0.001

 Negative

 Positive

Tumor deposits

<  0.001

1.70

1.39–2.08

<  0.001

 Absent

 Present

Histologic subtype (classical adenocarcinoma as reference)

<  0.001

<  0.001

 Classical adenocarcinoma

1

Reference

 Mucinous adenocarcinoma

1.14

0.93–1.39

0.20

 Signet-ring cell carcinoma

1.88

1.37–2.58

<  0.001

 Adenocarcinoma with mixed subtypes

1.89

1.25–2.85

0.003

Histologic subtype (adenocarcinoma with mixed subtypes as reference)

<  0.001

<  0.001

 Adenocarcinoma with mixed subtypes

1

Reference

 Classical adenocarcinoma

0.53

0.35–0.81

0.003

 Mucinous adenocarcinoma

0.60

0.40–0.90

0.01

 Signet-ring cell carcinoma

0.99

0.65–1.53

0.98