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Table 4 Univariate and multivariate analysis for the colorectal-specific overall survival of histologic subtypes in colorectal cancer

From: Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer

CharacteristicsUnivariate analysisMultivariate analysis  
 P valueHR95% CIP value
Sex0.06   
 Male    
 Female    
Age (yrs)<  0.0012.261.87–2.73<  0.001
  ≤ 66    
  > 66    
Tumor location<  0.001   
 Colon    
 Rectum    
Grade<  0.001  0.001
 Well differentiated 1Reference 
 Moderately differentiated 1.500.96–2.340.08
 Poorly differentiated or undifferentiated 2.061.30–3.280.002
TNM stage<  0.001  <  0.001
 0 + I 1Reference 
 II 2.041.24–3.350.01
 III 5.123.23–8.09<  0.001
 IV 15.399.55–24.79<  0.001
Race<  0.001   
 American Indian/Alaska Native    
 Asian or Pacific Islander    
 Black    
 White    
Insurance status<  0.001   
 Insured    
 Others    
Marital status<  0.001  0.003
 Married 1Reference 
 Widowed 1.401.10–1.780.01
 Others 1.331.08–1.630.01
CEA<  0.001  <  0.001
 Normal 1Reference 
 Borderline 1.430.45–4.510.54
 Elevated 1.761.44–2.15<  0.001
CRM<  0.0011.471.22–1.77<  0.001
 Negative    
 Positive    
Perineural invasion<  0.001   
 Negative    
 Positive    
Tumor deposits<  0.0011.701.39–2.08<  0.001
 Absent    
 Present    
Histologic subtype (classical adenocarcinoma as reference)<  0.001  <  0.001
 Classical adenocarcinoma 1Reference 
 Mucinous adenocarcinoma 1.140.93–1.390.20
 Signet-ring cell carcinoma 1.881.37–2.58<  0.001
 Adenocarcinoma with mixed subtypes 1.891.25–2.850.003
Histologic subtype (adenocarcinoma with mixed subtypes as reference)<  0.001  <  0.001
 Adenocarcinoma with mixed subtypes 1Reference 
 Classical adenocarcinoma 0.530.35–0.810.003
 Mucinous adenocarcinoma 0.600.40–0.900.01
 Signet-ring cell carcinoma 0.990.65–1.530.98
  1. Abbreviation: TNM tumor-node-metastasis, CEA carcinoembryonic antigen, CRM circumferential resection margin