Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer

BMC Cancer

Table 3 Comparisons of the 3-year colorectal cancer specific overall survival rates between classical adenocarcinoma and other histologic types

Characteristics	Classical adenocarcinoma (mean ± SD)	Mucinous adenocarcinoma (mean ± SD)	P₁^a	P₂^a	Signet-ring cell carcinoma (mean ± SD)	P₁^a	P₂^a	Adenocarcinoma with mixed subtypes (mean ± SD)	P₁^a
All	90.3 ± 0.4%	71.6 ± 1.3%	< 0.001	< 0.001	38.0 ± 5.8%	< 0.001	0.29	49.8 ± 5.2%	< 0.001
TNM stage
0 + I	96.3 ± 0.3%	91.0 ± 2.4%	< 0.001	0.32	94.3 ± 4.0%	0.21	0.53	85.9 ± 9.5%	0.03
II	90.2 ± 1.1%	85.5 ± 2.3%	0.04	0.83	71.6 ± 6.1%	< 0.001	0.15	88.7 ± 5.5%	0.43
III	84.1 ± 1.5%	72.0 ± 1.7%	< 0.001	< 0.001	41.4 ± 12.3%	< 0.001	0.51	41.7 ± 10.5%	< 0.001
IV	35.2 ± 2.9%	36.1 ± 2.5%	0.99	< 0.001	9.4 ± 4.8%	< 0.001	0.78	19.5 ± 7.2%	0.001
Tumor location
Colon	90.2 ± 0.5%	71.8 ± 1.4%	< 0.001	< 0.001	38.4 ± 6.6%	< 0.001	0.54	48.3 ± 5.8%	< 0.001
Rectum	90.4 ± 0.8%	70.4 ± 3.1%	< 0.001	0.10	26.6 ± 12.5%	< 0.001	0.19	56.4 ± 11.9%	< 0.001
Sex
Male	90.7 ± 0.5%	70.9 ± 2.2%	< 0.001	< 0.001	26.7 ± 11.5%	< 0.001	0.38	51.4 ± 5.2%	< 0.001
Female	89.8 ± 0.6%	72.3 ± 1.3%	< 0.001	< 0.001	45.9 ± 3.8%	< 0.001	0.50	48.8 ± 8.8%	< 0.001
Age (yrs)
≤ 66	92.9 ± 0.5%	74.7 ± 1.5%	< 0.001	< 0.001	39.8 ± 4.5%	< 0.001	0.12	53.4 ± 6.3%	< 0.001
> 66	86.9 ± 0.7%	68.6 ± 2.0%	< 0.001	< 0.001	39.1 ± 9.4%	< 0.001	0.99	47.8 ± 7.0%	< 0.001

Abbreviation: TNM tumor-node-metastasis
^a P1, comparisons using “classical adenocarcinoma” as the reference. P2, comparisons using “adenocarcinoma with mixed subtypes” as the reference

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