All patients | Restricted to any diagnosis of hypertension/edema/MI/HFa | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients | Deaths | Person years | Unadjusted HR (95% CI) | Adjustedb HR (95%CI) | P-value (trend) | Patients | Deaths | Person years | Unadjusted HR (95% CI) | Adjustedb HR (95%CI) | P-value (trend) | |
Esophageal | ||||||||||||
Non-user | 2365 | 1625 | 4336 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1097 | 763 | 1747 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
User | 343 | 219 | 471 | 1.47 (1.27, 1.69) | 1.28 (1.10, 1.50) | 0.002 | 233 | 148 | 285 | 1.29 (1.08, 1.55) | 1.07 (0.88, 1.30) | 0.502 |
1–12 prescriptions | 270 | 184 | 361 | 1.40 (1.20, 1.63) | 1.23 (1.04, 1.45) | (< 0.001) | 182 | 122 | 227 | 1.23 (1.02, 1.50) | 1.03 (0.83, 1.26) | (0.267) |
≥ 12 prescriptions | 73 | 35 | 110 | 2.02 (1.44, 2.84) | 1.74 (1.22, 2.49) | 51 | 26 | 59 | 1.69 (1.13, 2.52) | 1.41 (0.92, 2.16) | ||
1–365 DDDs | 266 | 180 | 347 | 1.42 (1.21, 1.65) | 1.25 (1.06, 1.47) | (0.001) | 175 | 117 | 214 | 1.24 (1.02, 1.51) | 1.03 (0.84, 1.28) | (0.326) |
≥ 365 DDDs | 77 | 39 | 124 | 1.76 (1.28, 2.43) | 1.52 (1.08, 2.13) | 58 | 31 | 71 | 1.53 (1.06, 2.21) | 1.27 (0.86, 1.88) | ||
Gastric | ||||||||||||
Non-user | 2005 | 1268 | 4558 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 906 | 541 | 1978 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
User | 372 | 199 | 612 | 1.38 (1.19, 1.60) | 1.27 (1.08, 1.50) | 0.004 | 264 | 138 | 440 | 1.36 (1.13, 1.64) | 1.18 (0.96, 1.46) | 0.125 |
1–12 prescriptions | 263 | 161 | 382 | 1.38 (1.17, 1.63) | 1.26 (1.06, 1.50) | (0.005) | 181 | 108 | 274 | 1.31 (1.07, 1.62) | 1.14 (0.91, 1.43) | (0.079) |
≥ 12 prescriptions | 109 | 38 | 230 | 1.37 (0.99, 1.91) | 1.35 (0.96, 1.91) | 83 | 30 | 166 | 1.56 (1.07, 2.29) | 1.38 (0.92, 2.07) | ||
1–365 DDDs | 259 | 155 | 364 | 1.39 (1.18, 1.65) | 1.26 (1.06, 1.51) | (0.006) | 175 | 102 | 251 | 1.32 (1.07, 1.63) | 1.14 (0.90, 1.43) | (0.080) |
≥ 365 DDDs | 113 | 44 | 248 | 1.34 (0.99, 1.82) | 1.32 (0.96, 1.83) | 89 | 36 | 189 | 1.49 (1.05, 2.10) | 1.34 (0.93, 1.96) |