| |
All patients
|
Restricted to any diagnosis of hypertension/edema/MI/HFa
|
|---|
| |
Patients
|
Deaths
|
Person years
|
Unadjusted HR (95% CI)
|
Adjustedb HR (95%CI)
|
P-value (trend)
|
Patients
|
Deaths
|
Person years
|
Unadjusted HR (95% CI)
|
Adjustedb HR (95%CI)
|
P-value (trend)
|
|---|
|
Esophageal
|
|
Non-user
|
2365
|
1625
|
4336
|
1.00 (ref. cat.)
|
1.00 (ref. cat.)
| |
1097
|
763
|
1747
|
1.00 (ref. cat.)
|
1.00 (ref. cat.)
| |
|
User
|
343
|
219
|
471
|
1.47 (1.27, 1.69)
|
1.28 (1.10, 1.50)
|
0.002
|
233
|
148
|
285
|
1.29 (1.08, 1.55)
|
1.07 (0.88, 1.30)
|
0.502
|
|
1–12 prescriptions
|
270
|
184
|
361
|
1.40 (1.20, 1.63)
|
1.23 (1.04, 1.45)
|
(< 0.001)
|
182
|
122
|
227
|
1.23 (1.02, 1.50)
|
1.03 (0.83, 1.26)
|
(0.267)
|
|
≥ 12 prescriptions
|
73
|
35
|
110
|
2.02 (1.44, 2.84)
|
1.74 (1.22, 2.49)
| |
51
|
26
|
59
|
1.69 (1.13, 2.52)
|
1.41 (0.92, 2.16)
| |
|
1–365 DDDs
|
266
|
180
|
347
|
1.42 (1.21, 1.65)
|
1.25 (1.06, 1.47)
|
(0.001)
|
175
|
117
|
214
|
1.24 (1.02, 1.51)
|
1.03 (0.84, 1.28)
|
(0.326)
|
|
≥ 365 DDDs
|
77
|
39
|
124
|
1.76 (1.28, 2.43)
|
1.52 (1.08, 2.13)
| |
58
|
31
|
71
|
1.53 (1.06, 2.21)
|
1.27 (0.86, 1.88)
| |
|
Gastric
|
|
Non-user
|
2005
|
1268
|
4558
|
1.00 (ref. cat.)
|
1.00 (ref. cat.)
| |
906
|
541
|
1978
|
1.00 (ref. cat.)
|
1.00 (ref. cat.)
| |
|
User
|
372
|
199
|
612
|
1.38 (1.19, 1.60)
|
1.27 (1.08, 1.50)
|
0.004
|
264
|
138
|
440
|
1.36 (1.13, 1.64)
|
1.18 (0.96, 1.46)
|
0.125
|
|
1–12 prescriptions
|
263
|
161
|
382
|
1.38 (1.17, 1.63)
|
1.26 (1.06, 1.50)
|
(0.005)
|
181
|
108
|
274
|
1.31 (1.07, 1.62)
|
1.14 (0.91, 1.43)
|
(0.079)
|
|
≥ 12 prescriptions
|
109
|
38
|
230
|
1.37 (0.99, 1.91)
|
1.35 (0.96, 1.91)
| |
83
|
30
|
166
|
1.56 (1.07, 2.29)
|
1.38 (0.92, 2.07)
| |
|
1–365 DDDs
|
259
|
155
|
364
|
1.39 (1.18, 1.65)
|
1.26 (1.06, 1.51)
|
(0.006)
|
175
|
102
|
251
|
1.32 (1.07, 1.63)
|
1.14 (0.90, 1.43)
|
(0.080)
|
|
≥ 365 DDDs
|
113
|
44
|
248
|
1.34 (0.99, 1.82)
|
1.32 (0.96, 1.83)
| |
89
|
36
|
189
|
1.49 (1.05, 2.10)
|
1.34 (0.93, 1.96)
| |
- aRestricted to patients with any diagnosis of hypertension, edema, myocardial infarction or heart failure at any time prior to esophageal or gastric cancer diagnosis.
- bAdjusted for age at diagnosis, sex, year of diagnosis, deprivation, radiotherapy within 6 months, chemotherapy within 6 months, surgery within 6 months, comorbidities (prior to cancer diagnosis, including cerebrovascular disease, chronic pulmonary disease, congestive heart disease, diabetes, myocardial infarction, peptic ulcer disease, peripheral vascular disease, renal disease, rheumatological disease, liver disease), and other medication use (statins, aspirin, time-varying after diagnosis)
