Fig. 4

Correlation between epidermal growth factor receptor (EGFR) expression and tumor uptake of radiolabeled cetuximab. (a) A significant correlation of EGFR expression level and tumor uptake of [¹¹¹In]In-DOTA-cetuximab was noted within tumor models of non-small cell lung cancer. Each data represents the mean ± SD of n = 5 to 7 per tumor model. (b) Tumor uptake of [⁶⁴Cu]Cu-DOTA-cetuximab in positron emission tomography (PET) (mean standardized uptake values [SUV mean]) is correlated with the EGFR expression level. Each data point represents SUVmean of each NSCLC tumor (8 cell lines, n = 2 per group) left panel: (a), right panel (b)