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Table 2 Univariate and Multivariate Logistic Regression for AKI (KDIGO)

From: Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin

VariablesOR (95% CI)Univariate
p value
OR (95% CI)Multivariate
p value
Age, ≥60 years1.1 (0.5–2.3)0.85  
Male gender0.9 (0.4–2.2)0.81  
ECOG performance status, ≥20.4 (0.1–2.3)0.34  
Hypertension, yes2.1 (0.7–6.1)0.172.7 (1.1–6.6)0.03
Diabetes, yes1.7 (0.3–8.4)0.54  
Cognitive impairment, yes0.4 (0.1–1.8)0.25  
CCI, ≥ 21.5 (0.5–4.1)0.45  
Number of nephrotoxic co-medications, ≥ 22.1 (0.8–5.4)0.121.9 (0.7–5.2)0.20
Smoking, ≥10 pack-years1.4 (0.6–3.4)0.39  
Alcohol, ≥14 U/week1.8 (0.8–4.0)0.172.3 (0.7–7.0)0.15
Primary tumor site, not oropharynx0.6 (0.3–1.5)0.32  
CRINV, yes3.0 (1.2–7.3)0.024.3 (1.6–11.3)0.003
  1. Note: Bold values in the univariate logistic regression model indicate p-values <0.20 as criterion for selection and entry into the multivariate analysis. Significant p-values in the multivariate analysis model (<0.05) are also denoted in bold.
  2. Abbreviations: KDIGO kidney disease improving global outcomes definition and staging system, OR odds ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group Performance Status Score, CCI Age-adjusted Charlson Comorbidity Index, CINV chemoradiation-induced nausea and vomiting