Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin

Table 2 Univariate and Multivariate Logistic Regression for AKI (KDIGO)

Variables	OR (95% CI)	Univariate p value	OR (95% CI)	Multivariate p value
Age, ≥60 years	1.1 (0.5–2.3)	0.85
Male gender	0.9 (0.4–2.2)	0.81
ECOG performance status, ≥2	0.4 (0.1–2.3)	0.34
Hypertension, yes	2.1 (0.7–6.1)	0.17	2.7 (1.1–6.6)	0.03
Diabetes, yes	1.7 (0.3–8.4)	0.54
Cognitive impairment, yes	0.4 (0.1–1.8)	0.25
CCI, ≥ 2	1.5 (0.5–4.1)	0.45
Number of nephrotoxic co-medications, ≥ 2	2.1 (0.8–5.4)	0.12	1.9 (0.7–5.2)	0.20
Smoking, ≥10 pack-years	1.4 (0.6–3.4)	0.39
Alcohol, ≥14 U/week	1.8 (0.8–4.0)	0.17	2.3 (0.7–7.0)	0.15
Primary tumor site, not oropharynx	0.6 (0.3–1.5)	0.32
CRINV, yes	3.0 (1.2–7.3)	0.02	4.3 (1.6–11.3)	0.003

Note: Bold values in the univariate logistic regression model indicate p-values <0.20 as criterion for selection and entry into the multivariate analysis. Significant p-values in the multivariate analysis model (<0.05) are also denoted in bold.
Abbreviations: KDIGO kidney disease improving global outcomes definition and staging system, OR odds ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group Performance Status Score, CCI Age-adjusted Charlson Comorbidity Index, CINV chemoradiation-induced nausea and vomiting

ISSN: 1471-2407