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Table 1 Body weight, diarrhea score, histologic findings, goblet cell count, and laboratory test

From: Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis

  Treatment group
Control DPP-4i 5-FU 5-FU + DPP4i
Body weight change – day 5 (%) 2.83 ± 1.45 −1.12 ± 2.95 *-14.03 ± 1.71 −13.65 ± 1.32
Diarrhea score – day 4 (point) 0.67 ± 0.58 0.50 ± 0.75 *2.33 ± 0.58 ‡1.83 ± 0.75
Histologic examination of small intestine
 Villus height (μm) 422.7 ± 78.2 366.9 ± 21.0 *318.2 ± 45.8 ‡345.1 ± 27.3
 Crypt depth (μm) 87.1 ± 10.2 88.3 ± 5.9 *137.6 ± 15.3 ‡109.9 ± 12.7
 Villus/crypt ratio 4.85 ± 1.4 4.16 ± 1.0 *2.32 ± 1.3 ‡3.14 ± 1.7
 Goblet cell count (/field) 6.33 ± 2.08 4.33 ± 0.82 *2.33 ± 0.58 ‡4.17 ± 0.75
Lab tests
 WBC (K/uL) 5.32 ± 0.50 3.57 ± 1.53 *0.65 ± 0.15 0.58 ± 0.10
 Hb (g/dL) 13.7 ± 0.06 14.4 ± 1.00 *10.7 ± 0.30 10.4 ± 0.34
 PLT (M/mm3) 122.6 ± 2.31 106.8 ± 3.97 *33.3 ± 4.22 28.3 ± 3.15
  1. *P < 0.05 vs control, ‡P < 0.05 vs 5-FU