Table 1 Body weight, diarrhea score, histologic findings, goblet cell count, and laboratory test
From: Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis
| Â | Treatment group | |||
|---|---|---|---|---|
Control | DPP-4i | 5-FU | 5-FU + DPP4i | |
Body weight change – day 5 (%) | 2.83 ± 1.45 | −1.12 ± 2.95 | *-14.03 ± 1.71 | −13.65 ± 1.32 |
Diarrhea score – day 4 (point) | 0.67 ± 0.58 | 0.50 ± 0.75 | *2.33 ± 0.58 | ‡1.83 ± 0.75 |
Histologic examination of small intestine | ||||
 Villus height (μm) | 422.7 ± 78.2 | 366.9 ± 21.0 | *318.2 ± 45.8 | ‡345.1 ± 27.3 |
 Crypt depth (μm) | 87.1 ± 10.2 | 88.3 ± 5.9 | *137.6 ± 15.3 | ‡109.9 ± 12.7 |
 Villus/crypt ratio | 4.85 ± 1.4 | 4.16 ± 1.0 | *2.32 ± 1.3 | ‡3.14 ± 1.7 |
 Goblet cell count (/field) | 6.33 ± 2.08 | 4.33 ± 0.82 | *2.33 ± 0.58 | ‡4.17 ± 0.75 |
Lab tests | ||||
 WBC (K/uL) | 5.32 ± 0.50 | 3.57 ± 1.53 | *0.65 ± 0.15 | 0.58 ± 0.10 |
 Hb (g/dL) | 13.7 ± 0.06 | 14.4 ± 1.00 | *10.7 ± 0.30 | 10.4 ± 0.34 |
 PLT (M/mm3) | 122.6 ± 2.31 | 106.8 ± 3.97 | *33.3 ± 4.22 | 28.3 ± 3.15 |