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Table 1 Patients characteristics

From: Systemic high-dose intravenous methotrexate in patients with central nervous system metastatic breast cancer

 

N

%

Age Median: 59 y (37–84)

Cycles of CT: 3 (1–7)

BM

22

100

 Parenchymal

17

77

 Leptomeningeal

8

36

Lines prior of CT

 ≤ 3

8

36

 > 3

14

64

HER-2 status

 Positive

13

59

 Negative

8

36

 Not Known

1

5

Hormone Receptors status

 Positive

11

50

 Negative

10

45

 Not Known

1

5

Triple Negative

2

9

CNS Radiotherapy

 Yes

15

68

 No

7

32

Other site of metastases

 Yes

20

81

 No

2

9

Concomitant treatment

 Yes

14

64

  Trastuzumab intravenous

11

50

  MTX intrathecal

2

9

  Lapatinib

1

5

 No

7

32