Skip to main content

Advertisement

Table 2 Multivariate Cox regression analyses of potential prognostic factors for OS and PFS

From: Tumor-associated macrophages predict prognosis in diffuse large B-cell lymphoma and correlation with peripheral absolute monocyte count

Variables OS PFS
HR(95%CI) P HR(95%CI) P
Age
 ≤ 60 years/>60 years 0.987 (0.674–1.444) 0.946 0.835 (0.562–1.241) 0.373
ECOG-PS
 1/>1 1.126 (0.725–1.749) 0.596 1.037 (0.668–1.610) 0.872
Extranodal sites
 ≤ 1/>1 1.019 (0.610–1.705) 0.941 1.038 (0.621–1.733) 0.888
Ann Arbor stage
 IorII/IIIorIV 1.620 (1.006–2.606) 0.047 1.862 (1.157–2.995) 0.010
LDH
 ≤ normal/> normal 1.881 (1.214–2.916) 0.005 1.815 (1.173–2.810) 0.007
IPI score
 0–2/3–5 1.167 (0.562–2.424) 0.679 1.320 (0.631–2.760) 0.461
AMC
 <460/ul/≥460/ul 1.658 (1.124–2.446) 0.011 1.675 (1.142–2.457) 0.008
Treatment
 R-CHOP/CHOP 1.978 (1.269–3.082) 0.003 1.780 (1.149–2.756) 0.010
CD68
 low/high 1.237 (0.710–2.156) 0.453 1.369 (0.789–2.376) 0.264
CD163
 low/high 2.265 (1.280–4.008) 0.005 1.925 (1.125–3.291) 0.017
  1. Abbreviations: OS overall survival, PFS progression-free survival, HR hazard ratio, CI confidence interval, ECOG-PS Eastern Cooperative Oncology Group performance status, LDH lactate dehydrogenase, IPI International Prognostic Index, AMC absolute monocyte count, CHOP cyclophosphamide hydroxydaunorubicin vincristine prednisone, R-CHOP rituximab-cyclophosphamidehydroxydaunorubicin vincristine prednisone