Fig. 6
From: Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study
The activation of Myc oncogenic signature in DKI mice. a GSEA shows enrichment of differentiation and apoptosis gene sets in DKI groups compared with Dnmt3aR878H/+ group. b GSEA shows enrichment of Myc oncogenic signature and Myc target gene sets in DKI group compared with Dnmt3aR878H/+ group. NES, normalized enrichment score. c Heat map of up-regulated Myc and Myc target genes in DKI mice compared with WT, Dnmt3aR878H/+ and NrasG12D/+ mice. d The gene expression levels were validated by real-time RT-PCR. Primers were listed in Additional file 3: Table S3. e Western blot analysis of cMyc and p62-cMyc. Horizontal bars correspond to Mean ± SEM values. * P < 0.05, ** P < 0.01, ***P < 0.001, significance was determined by two-tailed Student’s t test