Fig. 2
From: Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study
DKI mice develop a more severe AML compared with Dnmt3aR878H/+ mice. a Blood routine analysis of indicated mice 4 months after pIpC induction. b Morphological analysis of BM cells with Wright’s staining and quantification analysis of immature cells with a high nuclear/cytoplasmic ratio and fine chromatin in BM. c Flow cytometric analysis of BM cells from each group. Myeloid cells (Gr-1+ Mac-1+), B lymphocyte (B220+), T lymphocyte (CD3+). d Flow cytometric quantification of hematopoietic progenitor cell populations in BM of each group. LSK (Lineage− Sca-1+ c-Kit+), LRP (CD150− CD48+ LSK), MPP (CD150− CD48− LSK), LT-HSC (CD150+ CD48− LSK), ST-HSC (CD150+ CD48+ LSK), GMP (CD34+ CD16/32high LK), CMP (CD34+ CD16/32med LK), MEP (CD34− CD16/32low LK). n = 10 for each group. Data were shown as Mean ± SEM values. * P < 0.05, *** P < 0.001, significance was determined by two-tailed Student’s t test