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Table 1 Patients’ characteristics in the sorafenib group and the HAIC group

From: Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma: SCOOP-2 trial

Variables

Sorafenib group (n = 33)

HAIC group (n = 35)

P

Sex

 Male/Female

27 / 6

28 / 7

1.000

Mean age (years)

70.9 ± 9.1

72.0 ± 7.0

0.571

Cause

 HCV / HBV / NBNC

20 / 4 / 10

21 / 3 / 11

0.308

Previous treatment

 Ablation/TACE+TAE/None

1/20/12

2/24/9

0.308

BCLC

 A / B / C

2 / 13 /18

2 /14 /19

0.994

UICC

 II/IIIA/IIIB/IIIC/IVA/IVB

14/3/7/1/3/5

15/2/6/2/4/6

0.802

Child-Pugh class

 5 / 6 / 7

10 /19 /4

20 / 11 / 4

0.061

PVTT

 yes / no

22 / 11

21 / 14

0.621

Extrahepatic metastasis

 yes / no

8 / 25

10 / 25

0.786

Gastroesophageal varices

 yes / no

10 / 23

5 / 30

0.099

AFP (ng/mL) a

216.7 (5–161,160)

67.3 (2–281,600)

0.688

DCP (mAU/mL) a

1068 (14–272,000)

335 (12–99,800)

0.364

  1. aData are the median values
  2. HCV hepatitis C virus, HBV hepatitis B virus, BCLC Barcelona Clinic Liver Cancer, UICC union for international cancer control, PVTT portal vein tumor thrombosis, AFP alpha-fetoprotein, DCP des-gamma carboxy-prothrombin