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Table 2 Primary endpoint and secondary endpoints

From: Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study

Characteristic Groups P value Group1 (FTMDT) P value
1(FTMDT) 2(Conventional) Subgroup 1a Subgroup 1b
Total in-hospital days, M (IQR) 13 (11–17) 23.5 (15–42) 0.0001 13 (11–16) 14 (12–17) 0.1951
Surgery
 Surgery duration, min, M (IQR) 155 (129–180) 150 (122–183) 0.8005 155 (140–180) 150 (120–180) 0.1028
 Blood loss, mL, M (IQR)) 100 (50–200) 150 (100–200) 0.0014 100 (50–150) 100 (100–200) 0.0150
 Intraoperative complications, n (%) 2 (1.2) 1 (0.6) 1.0000 0 (0.0) 2 (2.4) 0.1480
 Postoperative in-hospital complications, n (%) 11 (6.4) 25 (14.7) 0.0140 5 (5.7) 6 (7.1) 0.7700
  Wound infection 1 (1) 0 (0) 1.0000 1 (1) 0 (0) 1.0000
  Anastomotic leakage 0 (0) 1 (1) 1.0000 0 (0) 1 (1) 1.0000
 Readmission < 30 days, n (%) 10 (5.8) 9 (5.3) 0.8340 6 (6.9) 4 (4.7) 0.5390
 Ambulation onset, h, M, (IQR) 24 (24–48) 48 (48–72) 0.0001 24 (24–48) 48 (24–48) 0.1064
 Days to flatus, M ± SD 56 ± 26 71 ± 27 < 0.0001 51 ± 25 62 ± 26 0.0121
 Days to defecation, M (IQR) 85 (55–97) 96 (69–129) 0.0010 76 (48–96) 90 (72–103) 0.0345
 Days to fluid diet resumption, M (IQR) 24 (24–48) 96 (72–120) 0.0001 24 (24–24) 24 (24–48) 0.1624
 Postoperative days, M (IQR) 6 (5–7) 9 (7–11) 0.0001 6 (4–8) 6 (5–7) 0.2160
 Surgical protocol compliance, M (IQR) 9 (8–10) 12 (12–12) 0.0001 9 (8–10) 9 (8–10) 0.2235
 Surgical costs, RMB, M (IQR) 29,678 (25868–35,045) 33,559 (29627–41,452) 0.0001 32,811(28062–37,117) 27,156(24490–32,684) 0.0001
Chemotherapy
 Patients received chemotherapy, n (%) 105 (62.5) 103 (63.2) 0.9100 55 (63.2) 50 (61.7) 0.8740
 Patients with any grade AEs, n (%) 94 (94.0) 92 (96.8) 0.4990 48 (92.3) 46 (95.8) 0.6790
 Patients with grade 3–4 AEs, n (%) 28 (28.0) 28 (29.5) 0.875 14 (26.9) 14 (29.2) 0.8270
 Cost for chemotherapy, RMB, M (IQR) 100,999 (59021–115,102) 104,256 (59954–128,233) 0.1410 100,414 (38221–117,460) 102,353 (64528–113,722) 0.7274
Survival
 5-year DFS (%, 95CI) 82.6 (75.6–87.8) 80.0 (73.0–85.4) 0.2780 81.2 (70.8–88.3) 83.7 (72.8–90.5) 0.7560
 5-year OS (%, 95CI) 87.1 (80.7–91.5) 87.1 (80.8–91.4) 0.7420 83.7 (73.6–90.2) 90.7% (81.5–95.5) 0.2540
  1. FTMDT Fast-track multi-discipline treatment, M (IQR) Median (interquartile range), M ± SD Mean ± standard deviation, n number, h hour, AEs Adverse events, RMB Ren Min Bi, DFS Disease free survival, OS Overall survival, CI Confidence interval