Fig. 1

a Tumor-directed treatment over time schematic from melanoma diagnosis until time of death. b-e Immunohistological staining: b Melan A: 5 melanoma cells with intense red staining are shown that surround 1 carcinoma cell with no coloration. c TTF-1 expression is shown in pulmonary adenocarcinoma cells, but not in the melanoma cells. d May-Grünwald-Giemsa (MGG) staining: 2 melanoma cells and 1 adenocarcinoma cell with cytoplasmic inclusions. e HMB45 staining: red stained melanoma cells with 1 uncolored carcinoma cell is shown. f MRI scans of LM are shown in contrast-enhanced T1 sequence and T2-FLAIR at baseline and at 8-week follow-up visit. In comparison to baseline, follow-up scans showed LM disease progression. White arrows indicate LM in T1 scans. In the T2-FLAIR scans, hyperintensities tracking along the sulci clearly indicate LM