Fig. 6

BM-1197 exerted strong anti-tumor effect in OCI-Ly8 xenograft models. a. Tumor volumes were measured at indicated days. Compared with control group, BM-1197 could inhibit OCI-Ly8 subcutaneous xenografts tumor growth significantly. Data are shown as mean ± S.E. of five mice in each group. ***: P < 0.001. b. OCI-Ly8 cells were injected into NOD/SCID mice as indicated. After treated with BM-1197 12 days, mice were sacrificed to harvest tumors. c. The tumor weight was supressed by BM-1197 significantly compared with vehicle group. Data are shown as mean ± S.E. of five mice in each group. *: P < 0.05. d. BM-1197 was well tolerated in those mice since no obvious weight loss upon treatment