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Fig. 4 | BMC Cancer

Fig. 4

From: Synergism of wt-p53 and synthetic material in local nano-TAE gene therapy of hepatoma: comparison of four systems and the possible mechanism

Fig. 4

VX2 tumor can be shown clearly by CT on the left lobe of liver (T, area showed by white cross) before emulsion injection. After in vivo intra-arterial injection of PEGFP-C2-wt-P53/lipiodol (A), L-nanoplex/lipiodol (E), U-nanoplex/lipiodol (B), Ca-nanoplexCa-nanoplex/lipiodol (C), Pll-nanoplex/lipiodol (D), nanoplex emulsion in group D displayed significantly stronger and more selectively deposits in tumor area (D, area showed by black cross), compared to the slight but selective deposits in group B (B, area showed by black cross), whereas emulsions in group A, C, E produced no tumor-selective retention potency but diffuse distribution in liver. In contrast to group A, B, C and E, EGFP-wt-P53 expression was observed by fluorescence microscope (FM) for green fluorescence (the arrow) and by western blot for a ∼ 72 kDa molecular weight band only in tumor of group D

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BMC Cancer

ISSN: 1471-2407

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