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Fig. 3 | BMC Cancer

Fig. 3

From: Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase

Fig. 3

Effects of HJNO or MMC on DNA unwinding of BLM helicase. aThe effects of HJNO on DNA unwinding of BLM helicase. b The effects of 1.67, 6.67, 13.34 and 50 μmol/L HJNO on DNA unwinding time curve of BLM helicase. c The effects of MMC on DNA unwinding of BLM helicase; d The effects of 0.2, 2 and 2.7 μmol/L MMC on DNA unwinding time curve of BLM helicase. Note: A1 is the fluorescence anisotrophy of BLM binding DNA and small molecules. A2 is the fluorescence anisotrophy after adding 0.2 mmol/L ATP

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