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Table 5 Synergistic effect of rs1047972, rs911160, rs2241909, rs2289590 and rs11084490 polymorphisms on gastric cancer risk

From: Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Risk genotypes

All type GC

P value

OR (95%CI)

Risk-free genotypes

1 (ref)

Two risk SNPs

 rs1047972(CT)/rs911160(CC)

2.29 (1.32–3.97)

0.003

 rs1047972(CT)/rs2241909(AG + GG)

1.61 (1.14–2.28)

0.006

 rs1047972(CT)/rs2289590(AC + CC)

1.87 (1.31–2.66)

< 0.001

 rs1047972(CT)/rs11084490(CG + GG)

1.51 (1.03–2.22)

0.034

 rs911160(CC)/rs2241909(AG + GG)

1.60 (1.11–2.32)

0.011

 rs911160(CC)/rs2289590(AC + CC)

2.19 (1.51–3.18)

< 0.001

 rs911160(CC)/rs11084490(CG + GG)

1.84 (1.19–2.83)

0.005

 rs2241909(AG + GG)/rs2289590(AC + CC)

2.09 (1.50–2.92)

< 0.001

 rs2241909(AG + GG)/rs11084490(CG + GG)

1.63 (1.17–2.28)

0.004

 rs2289590(AC + CC)/rs11084490(CG + GG)

2.12 (1.52–2.98)

< 0.001

Three risk SNPs

 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)

1.68 (1.22–2.30)

0.001

 rs1047972(CT)/rs911160(CC)/rs2289590(AC + CC)

2.09 (1.52–2.88)

< 0.001

 rs1047972(CT)/rs911160(CC)/rs11084490(CG + GG)

1.87 (1.31–2.66)

< 0.001

 rs1047972(CT)/rs2241909(AG + GG)/rs2289590(AC + CC)

1.90 (1.44–2.50)

< 0.001

 rs1047972(CT)/rs2241909(AG + GG)/rs11084490(CG + GG)

1.64 (1.24–2.19)

0.001

 rs1047972(CT)/rs2289590(AC + CC)/rs11084490(CG + GG)

1.81 (1.36–2.42)

< 0.001

 rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC)

1.89 (1.42–2.50)

< 0.001

 rs911160(CC)/rs2241909(AG + GG)/rs11084490(CG + GG)

1.64 (1.22–2.20)

0.001

 rs911160(CC)/rs2289590(AC + CC)/rs11084490(CG + GG)

2.00 (1.49–2.70)

< 0.001

 rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG)

1.93 (1.47–2.53)

< 0.001

Four risk SNPs

 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC)

1.86 (1.44–2.40)

< 0.001

 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)/rs11084490(CG + GG)

1.68 (1.29–2.19)

< 0.001

 rs1047972(CT)/rs911160(CC)/rs2289590(AC + CC)/rs11084490(CG + GG)

1.97 (1.51–2.57)

< 0.001

 rs1047972(CT)/rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG)

1.85 (1.45–2.35)

< 0.001

 rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG)

1.84 (1.44–2.35)

< 0.001

Five risk SNPs

 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG)

1.83 (1.46–2.29)

< 0.001

  1. Statistically significant values are highlighted in bold (P ≤ 0.05)
  2. GC Gastric cancer, OR Odds ratio, CI, Confidence interval, SNP, Single nucleotide polymorphism, Ref Reference
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BMC Cancer

ISSN: 1471-2407

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