Skip to main content

Advertisement

Table 5 Synergistic effect of rs1047972, rs911160, rs2241909, rs2289590 and rs11084490 polymorphisms on gastric cancer risk

From: Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Risk genotypes All type GC P value
OR (95%CI)
Risk-free genotypes 1 (ref)
Two risk SNPs
 rs1047972(CT)/rs911160(CC) 2.29 (1.32–3.97) 0.003
 rs1047972(CT)/rs2241909(AG + GG) 1.61 (1.14–2.28) 0.006
 rs1047972(CT)/rs2289590(AC + CC) 1.87 (1.31–2.66) < 0.001
 rs1047972(CT)/rs11084490(CG + GG) 1.51 (1.03–2.22) 0.034
 rs911160(CC)/rs2241909(AG + GG) 1.60 (1.11–2.32) 0.011
 rs911160(CC)/rs2289590(AC + CC) 2.19 (1.51–3.18) < 0.001
 rs911160(CC)/rs11084490(CG + GG) 1.84 (1.19–2.83) 0.005
 rs2241909(AG + GG)/rs2289590(AC + CC) 2.09 (1.50–2.92) < 0.001
 rs2241909(AG + GG)/rs11084490(CG + GG) 1.63 (1.17–2.28) 0.004
 rs2289590(AC + CC)/rs11084490(CG + GG) 2.12 (1.52–2.98) < 0.001
Three risk SNPs
 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG) 1.68 (1.22–2.30) 0.001
 rs1047972(CT)/rs911160(CC)/rs2289590(AC + CC) 2.09 (1.52–2.88) < 0.001
 rs1047972(CT)/rs911160(CC)/rs11084490(CG + GG) 1.87 (1.31–2.66) < 0.001
 rs1047972(CT)/rs2241909(AG + GG)/rs2289590(AC + CC) 1.90 (1.44–2.50) < 0.001
 rs1047972(CT)/rs2241909(AG + GG)/rs11084490(CG + GG) 1.64 (1.24–2.19) 0.001
 rs1047972(CT)/rs2289590(AC + CC)/rs11084490(CG + GG) 1.81 (1.36–2.42) < 0.001
 rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC) 1.89 (1.42–2.50) < 0.001
 rs911160(CC)/rs2241909(AG + GG)/rs11084490(CG + GG) 1.64 (1.22–2.20) 0.001
 rs911160(CC)/rs2289590(AC + CC)/rs11084490(CG + GG) 2.00 (1.49–2.70) < 0.001
 rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG) 1.93 (1.47–2.53) < 0.001
Four risk SNPs
 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC) 1.86 (1.44–2.40) < 0.001
 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)/rs11084490(CG + GG) 1.68 (1.29–2.19) < 0.001
 rs1047972(CT)/rs911160(CC)/rs2289590(AC + CC)/rs11084490(CG + GG) 1.97 (1.51–2.57) < 0.001
 rs1047972(CT)/rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG) 1.85 (1.45–2.35) < 0.001
 rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG) 1.84 (1.44–2.35) < 0.001
Five risk SNPs
 rs1047972(CT)/rs911160(CC)/rs2241909(AG + GG)/rs2289590(AC + CC)/rs11084490(CG + GG) 1.83 (1.46–2.29) < 0.001
  1. Statistically significant values are highlighted in bold (P ≤ 0.05)
  2. GC Gastric cancer, OR Odds ratio, CI, Confidence interval, SNP, Single nucleotide polymorphism, Ref Reference