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Table 4 Risk of gastric cancer associated with studied polymorphisms

From: Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Genotypes

All type GC

Intestinal type GC

Diffuse type GC

OR (95%CI)

P value

AIC

OR (95%CI)

P value

AIC

OR (95%CI)

P value

AIC

rs2273535

 AA

1 (ref)

  

1 (ref)

  

1 (ref)

  

 AT

1.52 (0.90–2.56)

0.111

 

1.63 (0.81–3.28)

0.167

 

1.43 (0.75–2.75)

0.275

 

 TT

2.24 (0.71–7.07)

0.167

 

4.31 (0.54–33.93)

0.164

 

1.55 (0.42–5.69)

0.504

 

 AA:(TT + AT)a

1.61 (0.98–2.64)

0.058

 

1.82 (0.93–3.59)

0.080

 

1.45 (0.78–2.69)

0.230

 

  (AA+AT):TTb

1.96 (0.63–6.11)

0.245

 

3.70 (0.47–28.84)

0.211

 

1.38 (0.38–4.98)

0.620

 

  (AA+TT):ATc

1.43 (0.86–2.40)

0.166

 

1.50 (0.75–3.01)

0.248

 

1.38 (0.72–2.63)

0.322

 

rs1047972

 CC

1 (ref)

  

1 (ref)

  

1 (ref)

  

 CT

1.96 (1.05–3.65)

0.033

 

2.53 (1.02–6.30)

0.045

 

1.62 (0.76–3.44)

0.208

 

 TT

1.60 (0.30–8.43)

0.577

 

1.55 (0.17–13.64)

0.691

 

1.65 (0.18–14.51)

0.649

 

 CC:(TT + CT)a

1.92 (1.06–3.48)

0.030

14.083

2.39 (1.02–5.63)

0.045

13.186

1.62 (0.78–3.35)

0.189

 

  (CC + CT):TTb

1.40 (0.26–7.38)

0.685

 

1.32 (0.15–11.54)

0.802

 

1.49 (0.17–13.07)

0.715

  (CC + TT):CTc

1.94 (1.04–3.60)

0.036

13.924

2.50 (1.01–6.22)

0.047

12.993

1.60 (0.75–3.39)

0.219

rs911160

 GG

1 (ref)

  

1 (ref)

  

1 (ref)

  

 CG

1.14 (0.71–1.84)

0.579

 

1.06 (0.56–1.98)

0.850

 

1.22 (0.67–2.20)

0.510

 

 CC

5.56 (1.24–24.81)

0.025

 

4.92 (0.63–38.49)

0.129

 

6.19 (0.79–48.12)

0.081

 

 GG:(CC + CG)a

1.33 (0.84–2.12)

0.220

 

1.23 (0.67–2.28)

0.495

 

1.42 (0.80–2.54)

0.228

 

  (GG + CG):CCb

5.26 (1.19–23.22)

0.028

 

4.80 (0.62–36.95)

0.132

 

5.72 (0.74–43.93)

0.093

  (GG + CC):CGc

1.01 (0.63–1.62)

0.947

 

0.94 (0.50–1.75)

0.861

 

1.08 (0.60–1.94)

0.797

rs8173

 CC

1 (ref)

  

1 (ref)

  

1 (ref)

  

 CG

0.60 (0.36–0.99)

0.049

 

0.65 (0.33–1.27)

0.217

 

0.55 (0.29–1.05)

0.072

 

 GG

0.38 (0.18–0.79)

0.010

 

0.46 (0.17–1.21)

0.119

 

0.32 (0.13–0.77)

0.012

 

 CC:(GG + CG)a

0.54 (0.33–0.87)

0.012

14.844

0.61 (0.32–1.14)

0.125

 

0.49 (0.27–0.89)

0.021

14.213

  (CC + CG):GGb

0.49 (0.25–0.98)

0.043

13.343

0.57 (0.23–1.40)

0.226

 

0.44 (0.20–0.98)

0.044

12.817

  (CC + GG):CGc

0.76 (0.48–1.21)

0.250

 

0.78 (0.42–1.44)

0.431

 

0.74 (0.42–1.31)

0.315

 

rs2241909

 AA

1 (ref)

  

1 (ref)

  

1 (ref)

  

 AG

1.49 (0.92–2.40)

0.098

 

2.23 (1.16–4.27)

0.016

 

1.07 (0.59–1.93)

0.802

 

 GG

2.75 (0.97–7.76)

0.056

 

3.71 (0.82–16.80)

0.089

 

2.11 (0.58–7.65)

0.256

 

 AA:(GG + AG)a

1.61 (1.01–2.56)

0.041

 

2.38 (1.27–4.46)

0.007

14.096

1.17 (0.66–2.07)

0.587

 

 (AA+AG):GGb

2.27 (0.82–6.25)

0.112

 

2.63 (0.59–11.68)

0.203

 

2.03 (0.58–7.10)

0.268

 (AA + GG):AGc

1.32 (0.83–2.10)

0.235

 

1.93 (1.02–3.67)

0.042

14.061

0.97 (0.55–1.72)

0.934

rs2289590

 AA

1 (ref)

  

1 (ref)

  

1 (ref)

  

 AC

2.41 (1.47–3.98)

0.001

 

1.77 (0.92–3.42)

0.087

 

3.12 (1.68–5.80)

< 0.001

 

 CC

6.77 (2.24–20.47)

0.001

 

5.19 (1.14–23.56)

0.033

 

8.35 (1.88–37.11)

0.005

 

 AA:(CC + AC)a

2.78 (1.71–4.51)

< 0.001

14.723

2.04 (1.07–3.88)

0.028

 

3.58 (1.96–6.52)

< 0.001

14.096

  (AA + AC):CCb

4.23 (1.44–12.40)

0.009

12.253

3.74 (0.86–16.30)

0.079

 

4.72 (1.09–20.43)

0.038

11.605

  (AA+CC):ACc

1.77 (1.10–2.85)

0.017

14.846

1.32 (0.70–2.49)

0.378

 

2.27 (1.24–4.13)

0.007

14.203

rs758099

 CC

1 (ref)

  

1 (ref)

  

1 (ref)

  

 CT

0.81 (0.50–1.32)

0.414

 

0.95 (0.50–1.78)

0.877

 

0.72 (0.40–1.30)

0.280

 

 TT

1.81 (0.73–4.49)

0.196

 

2.08 (0.58–7.44)

0.258

 

1.61 (0.51–5.05)

0.407

 

 CC:(TT + CT)a

0.93 (0.59–1.48)

0.783

 

1.08 (0.59–1.99)

0.786

 

0.82 (0.47–1.45)

0.514

 

  (CC + CT):TTb

1.99 (0.82–4.79)

0.125

 

2.13 (0.61–7.38)

0.233

 

1.88 (0.62–5.67)

0.260

  (CC + TT):CTc

0.75 (0.47–1.19)

0.228

 

0.86 (0.46–1.59)

0.634

 

0.67 (0.38–1.18)

0.172

rs11084490

 CC

1 (ref)

  

1 (ref)

  

1 (ref)

  

 CG

1.50 (0.90–2.48)

0.114

 

1.78 (0.89–3.55)

0.102

 

1.30 (0.70–2.42)

0.390

 

 GG

–

–

 

–

–

 

–

–

 

 CC:(GG + CG)a

1.71 (1.04–2.81)

0.033

 

2.03 (1.02–4.04)

0.043

 

1.49 (0.81–2.75)

0.195

 

  (CC + CG):GGb

–

–

 

–

–

 

–

–

  (CC + GG):CGc

1.38 (0.84–2.28)

0.201

 

1.64 (0.82–3.27)

0.158

 

1.20 (0.65–2.23)

0.543

rs42873

 GG

1 (ref)

  

1 (ref)

  

1 (ref)

  

 CG

0.69 (0.43–1.12)

0.141

 

0.72 (0.38–1.35)

0.309

 

0.67 (0.37–1.22)

0.197

 

 CC

1.70 (0.45–6.41)

0.429

 

2.36 (0.29–19.17)

0.421

 

1.37 (0.28–6.58)

0.688

 

 GG:(CC + CG)a

0.75 (0.47–1.20)

0.244

 

0.79 (0.42–1.47)

0.467

 

0.72 (0.41–1.29)

0.279

 

  (GG + CG):CCb

1.95 (0.52–7.25)

0.316

 

2.67 (0.33–21.34)

0.354

 

1.59 (0.34–7.48)

0.553

  (GG + CC):CGc

0.67 (0.42–1.08)

0.107

 

0.69 (0.36–1.29)

0.246

 

0.66 (0.37–1.19)

0.170

  1. Statistically significant values are highlighted in bold (P ≤ 0.05). The inheritance model that best fits the data according to AIC is highlighted in bold
  2. GC Gastric cancer, OR Odds ratio, CI Confidence interval, AIC, Akaike information criterion, ORs 95%CIs and P values were estimated by multinomial logistic regression analysis, Ref Reference homozygote
  3. aDominant genetic model
  4. bRecessive genetic model
  5. cOverdominant genetic model
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