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Table 4 Risk of gastric cancer associated with studied polymorphisms

From: Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Genotypes All type GC Intestinal type GC Diffuse type GC
OR (95%CI) P value AIC OR (95%CI) P value AIC OR (95%CI) P value AIC
rs2273535
 AA 1 (ref)    1 (ref)    1 (ref)   
 AT 1.52 (0.90–2.56) 0.111   1.63 (0.81–3.28) 0.167   1.43 (0.75–2.75) 0.275  
 TT 2.24 (0.71–7.07) 0.167   4.31 (0.54–33.93) 0.164   1.55 (0.42–5.69) 0.504  
 AA:(TT + AT)a 1.61 (0.98–2.64) 0.058   1.82 (0.93–3.59) 0.080   1.45 (0.78–2.69) 0.230  
  (AA+AT):TTb 1.96 (0.63–6.11) 0.245   3.70 (0.47–28.84) 0.211   1.38 (0.38–4.98) 0.620  
  (AA+TT):ATc 1.43 (0.86–2.40) 0.166   1.50 (0.75–3.01) 0.248   1.38 (0.72–2.63) 0.322  
rs1047972
 CC 1 (ref)    1 (ref)    1 (ref)   
 CT 1.96 (1.05–3.65) 0.033   2.53 (1.02–6.30) 0.045   1.62 (0.76–3.44) 0.208  
 TT 1.60 (0.30–8.43) 0.577   1.55 (0.17–13.64) 0.691   1.65 (0.18–14.51) 0.649  
 CC:(TT + CT)a 1.92 (1.06–3.48) 0.030 14.083 2.39 (1.02–5.63) 0.045 13.186 1.62 (0.78–3.35) 0.189  
  (CC + CT):TTb 1.40 (0.26–7.38) 0.685   1.32 (0.15–11.54) 0.802   1.49 (0.17–13.07) 0.715
(CC + TT):CTc 1.94 (1.04–3.60) 0.036 13.924 2.50 (1.01–6.22) 0.047 12.993 1.60 (0.75–3.39) 0.219
rs911160
 GG 1 (ref)    1 (ref)    1 (ref)   
 CG 1.14 (0.71–1.84) 0.579   1.06 (0.56–1.98) 0.850   1.22 (0.67–2.20) 0.510  
 CC 5.56 (1.24–24.81) 0.025   4.92 (0.63–38.49) 0.129   6.19 (0.79–48.12) 0.081  
 GG:(CC + CG)a 1.33 (0.84–2.12) 0.220   1.23 (0.67–2.28) 0.495   1.42 (0.80–2.54) 0.228  
  (GG + CG):CCb 5.26 (1.19–23.22) 0.028   4.80 (0.62–36.95) 0.132   5.72 (0.74–43.93) 0.093
  (GG + CC):CGc 1.01 (0.63–1.62) 0.947   0.94 (0.50–1.75) 0.861   1.08 (0.60–1.94) 0.797
rs8173
 CC 1 (ref)    1 (ref)    1 (ref)   
 CG 0.60 (0.36–0.99) 0.049   0.65 (0.33–1.27) 0.217   0.55 (0.29–1.05) 0.072  
 GG 0.38 (0.18–0.79) 0.010   0.46 (0.17–1.21) 0.119   0.32 (0.13–0.77) 0.012  
 CC:(GG + CG)a 0.54 (0.33–0.87) 0.012 14.844 0.61 (0.32–1.14) 0.125   0.49 (0.27–0.89) 0.021 14.213
(CC + CG):GGb 0.49 (0.25–0.98) 0.043 13.343 0.57 (0.23–1.40) 0.226   0.44 (0.20–0.98) 0.044 12.817
  (CC + GG):CGc 0.76 (0.48–1.21) 0.250   0.78 (0.42–1.44) 0.431   0.74 (0.42–1.31) 0.315  
rs2241909
 AA 1 (ref)    1 (ref)    1 (ref)   
 AG 1.49 (0.92–2.40) 0.098   2.23 (1.16–4.27) 0.016   1.07 (0.59–1.93) 0.802  
 GG 2.75 (0.97–7.76) 0.056   3.71 (0.82–16.80) 0.089   2.11 (0.58–7.65) 0.256  
 AA:(GG + AG)a 1.61 (1.01–2.56) 0.041   2.38 (1.27–4.46) 0.007 14.096 1.17 (0.66–2.07) 0.587  
 (AA+AG):GGb 2.27 (0.82–6.25) 0.112   2.63 (0.59–11.68) 0.203   2.03 (0.58–7.10) 0.268
(AA + GG):AGc 1.32 (0.83–2.10) 0.235   1.93 (1.02–3.67) 0.042 14.061 0.97 (0.55–1.72) 0.934
rs2289590
 AA 1 (ref)    1 (ref)    1 (ref)   
 AC 2.41 (1.47–3.98) 0.001   1.77 (0.92–3.42) 0.087   3.12 (1.68–5.80) < 0.001  
 CC 6.77 (2.24–20.47) 0.001   5.19 (1.14–23.56) 0.033   8.35 (1.88–37.11) 0.005  
 AA:(CC + AC)a 2.78 (1.71–4.51) < 0.001 14.723 2.04 (1.07–3.88) 0.028   3.58 (1.96–6.52) < 0.001 14.096
(AA + AC):CCb 4.23 (1.44–12.40) 0.009 12.253 3.74 (0.86–16.30) 0.079   4.72 (1.09–20.43) 0.038 11.605
  (AA+CC):ACc 1.77 (1.10–2.85) 0.017 14.846 1.32 (0.70–2.49) 0.378   2.27 (1.24–4.13) 0.007 14.203
rs758099
 CC 1 (ref)    1 (ref)    1 (ref)   
 CT 0.81 (0.50–1.32) 0.414   0.95 (0.50–1.78) 0.877   0.72 (0.40–1.30) 0.280  
 TT 1.81 (0.73–4.49) 0.196   2.08 (0.58–7.44) 0.258   1.61 (0.51–5.05) 0.407  
 CC:(TT + CT)a 0.93 (0.59–1.48) 0.783   1.08 (0.59–1.99) 0.786   0.82 (0.47–1.45) 0.514  
  (CC + CT):TTb 1.99 (0.82–4.79) 0.125   2.13 (0.61–7.38) 0.233   1.88 (0.62–5.67) 0.260
  (CC + TT):CTc 0.75 (0.47–1.19) 0.228   0.86 (0.46–1.59) 0.634   0.67 (0.38–1.18) 0.172
rs11084490
 CC 1 (ref)    1 (ref)    1 (ref)   
 CG 1.50 (0.90–2.48) 0.114   1.78 (0.89–3.55) 0.102   1.30 (0.70–2.42) 0.390  
 GG    
 CC:(GG + CG)a 1.71 (1.04–2.81) 0.033   2.03 (1.02–4.04) 0.043   1.49 (0.81–2.75) 0.195  
  (CC + CG):GGb   
  (CC + GG):CGc 1.38 (0.84–2.28) 0.201   1.64 (0.82–3.27) 0.158   1.20 (0.65–2.23) 0.543
rs42873
 GG 1 (ref)    1 (ref)    1 (ref)   
 CG 0.69 (0.43–1.12) 0.141   0.72 (0.38–1.35) 0.309   0.67 (0.37–1.22) 0.197  
 CC 1.70 (0.45–6.41) 0.429   2.36 (0.29–19.17) 0.421   1.37 (0.28–6.58) 0.688  
 GG:(CC + CG)a 0.75 (0.47–1.20) 0.244   0.79 (0.42–1.47) 0.467   0.72 (0.41–1.29) 0.279  
  (GG + CG):CCb 1.95 (0.52–7.25) 0.316   2.67 (0.33–21.34) 0.354   1.59 (0.34–7.48) 0.553
  (GG + CC):CGc 0.67 (0.42–1.08) 0.107   0.69 (0.36–1.29) 0.246   0.66 (0.37–1.19) 0.170
  1. Statistically significant values are highlighted in bold (P ≤ 0.05). The inheritance model that best fits the data according to AIC is highlighted in bold
  2. GC Gastric cancer, OR Odds ratio, CI Confidence interval, AIC, Akaike information criterion, ORs 95%CIs and P values were estimated by multinomial logistic regression analysis, Ref Reference homozygote
  3. aDominant genetic model
  4. bRecessive genetic model
  5. cOverdominant genetic model