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Table 4 Age-adjusted Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between lactation practices and breast cancer as defined by gene-specific promoter methylation in breast tumor tissue (comparing parous case women with and without methylated breast cancer [N = 736]), Long Island Breast Cancer Study Project

From: Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer

 

Any Lactation

No Lactation

Gene promoter

Methylated/ Unmethylated

OR

95% CI

Methylated/ Unmethylated

OR

95% CI

APC

113/146

1.00

reference

218/211

1.33

0.97–1.81

BRCA1

166/107

1.00

reference

265/195

0.89

0.66–1.21

CDH1

19/228

1.00

reference

20/400

0.60

0.31–1.15

CCND2

51/196

1.00

reference

84/336

0.96

0.65–1.42

DAPK

41/206

1.00

reference

54/366

0.74

0.47–1.15

ESR1

117/151

1.00

reference

213/244

1.13

0.83–1.53

GSTP1

71/176

1.00

reference

113/307

0.91

0.64–1.30

HIN

160/87

1.00

reference

254/166

0.83

0.60–1.16

P16

10/243

1.00

reference

17/397

1.05

0.47–2.34

PGR

41/232

1.00

reference

46/414

0.63

0.40–0.99

RARB

70/177

1.00

reference

113/307

0.93

0.65–1.32

RASSF1A

214/33

1.00

reference

352/68

0.79

0.51–1.25

TWIST1

37/210

1.00

reference

61/359

0.96

0.62–1.50

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BMC Cancer

ISSN: 1471-2407

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