Fig. 8
From: Response of neuroblastoma cells to RF currents as a function of the signal frequency
Schematic representation of the cascade of events triggered by intermittent stimulation (5 min ON/3 h and 55 min OFF) with CRET at 448 kHz and 50 μA/mm2. Samples were studied at 5 min, 30 min, 4 h, 12 h or 24 h after onset of the initial, 5-min exposure interval. Dotted arrows: proposed action pathways. Solid arrows: confirmed pathways; ▲: increase, statistically significant; ▼: decrease, statistically significant;
: increase, not significant statistically;
: decrease, not significant statistically. The antiproliferative and proapoptotic effects observed at the end of the second day of intermittent stimulation would be mediated by electrically induced changes in the expression of proteins that regulate cell cycle phases, apoptosis and cell proliferation. See the discussion text for detailed explanation